EXPERIMENTAL SUBSTANTIATION OF THE USE OF COLLAGEN MEMBRANES FOR THE RECONSTRUCTION OF FULL-THICKNESS DEFECTS IN HYALINE CARTILAGE
https://doi.org/10.38181/2223-2427-2020-1-45-52
Abstract
Abstract. The article is devoted to the experimental study of the effectiveness of AMIC technology in the surgical treatment of full-thickness defects in hyaline cartilage. Purpose of the study - study the biological potential of collagen membranes and their ability to transform into cartilage tissue. The study was conducted on 4 pigs. On the joints of the hind limbs, full-thickness cartilage defects and implantation of 2 different collagen membranes were formed. Animals were removed from the experiment in the period 2,3,4,6 months after surgery. The article presents a morphological analysis of the nature of cartilage tissue regeneration 6 months after surgery. The study showed the high biological potential of collagen membranes and their ability to transform into hyaline cartilage.
About the Authors
G. D. Lazishvili
Pirogov Medical University
Russian Federation
Russian Federation
Lazishvili Guram Davidovich, MD., PhD, professor of department of traumatolog y and orthopaedy
1 Ostrovityanova st. Moscow, 117997
phone +7 (916) 657-59-96
K. A. Egiazaryan
Pirogov Medical University
Russian Federation
Russian Federation
Egiazaryan Karen Albertovich, MD., PhD., professor, chief of department of traumatolog y and orthopaedy
1 Ostrovityanova st. Moscow, 117997
D. V. Nikishin
Aptos Group LLC
Russian Federation
Russian Federation
Nikishin Dmitry Victorovich, Deputy gene. Research and Development Director
115432, Moscow, Proektiruemi proezd No 4062, d.6, str. 2, office 23
A. A. Voroncov
Clinic “Veterinary Center of Surgery and Oncology Dr. Vorontsov”
Russian Federation
Russian Federation
Voroncov Aleksand Alekseevich, MD., PhD., chief doctor of the clinic
Moscow Region, 142715, Sovhoz Lenina 3a
M. A. Shpak
Pirogov Medical University
Russian Federation
Russian Federation
Shpak Marya Alekseevna, resident of department of traumatolog y and orthopaedy
1 Ostrovityanova st. Moscow, 117997
D. V. Klinov
Laboratory of Medical Nanotechnologies
Russian Federation
Russian Federation
Klinov Dmitry Vladimirovich, Head Laboratory of Medical Nanotechnologies
119435, Moscow, Malaya Pirogovskaya, 1a
I. V. Sirotin
Pirogov Medical University
Russian Federation
Russian Federation
Sirotin Ivan Vladimirovich, MD, PhD., docent of department of traumatology and orthopaedy
1 Ostrovityanova st. Moscow, 117997
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For citations:
Lazishvili G.D., Egiazaryan K.A., Nikishin D.V., Voroncov A.A., Shpak M.A., Klinov D.V., Sirotin I.V. EXPERIMENTAL SUBSTANTIATION OF THE USE OF COLLAGEN MEMBRANES FOR THE RECONSTRUCTION OF FULL-THICKNESS DEFECTS IN HYALINE CARTILAGE. Surgical practice (Russia). 2020;(1):45-52. (In Russ.) https://doi.org/10.38181/2223-2427-2020-1-45-52
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