CORTISOL AND ALDOSTERONE ARE THE RISK FACTORS OF UROLITHIASIS
Abstract
The article is devoted to the study of functional and endocrine-metabolic correlation dependencies in response to parenteral administration of physiological solution and 0.06% sodium hypochlorite solution in the experiment in rats. The study was performed on 35 white mongrel rats weighing 249-450 grams. In the group of intact animals was 5 rats, they were not subjected to any effects. The control group consisted of 15 rats, they intraperitoneally injected 1.5 ml of a 0.9% solution of sodium chloride during 4 days. The experimental group consisted of 15 rats, they intraperitoneally injected 1.5 ml of 0.06% (2.2-2.5 mg / kg / day) solution of sodium hypochlorite during 4 days.Experimental studies showed that in the control and study groups there were two different metabolic processes: normal metabolism in the control group and hypocatabolic metabolism in the study group. The vector unidirectionality in the comparison groups was observed only in the analysis of the change in the concentration of parathyroid hormone. The decrease in the level of cortisol and aldosterone in the blood of the animals in the study group was accompanied by a strong direct correlation with the excreted fraction of uric acid, the excreted fraction of magnesium and the concentration of uric acid in the urine, a moderate direct dependence on the excreted calcium fraction and the concentration of calcium in the urine, weak direct dependence on the excreted fraction of phosphorus and the concentration of phosphorus in the urine. The study of the role of cortisol and aldosterone as an extrarenal risk factor for the formation of urinary stones can contribute to understanding the pathogenesis of nephrolithiasis and the development of new methods for the prevention and metaphylaxis of urolithiasis
About the Authors
V. V. Ivashchenko
FGBI "United Hospital and Polyclinic" Administrative Department of the President of Russian Federation
Russian Federation
Russian Federation
I. V. Chernyshev
FGBI "United Hospital and Polyclinic" Administrative Department of the President of Russian Federation
Russian Federation
Russian Federation
V. I. Kirpatovsky
N.A.Lopatkin Research Institute of Urology and Interventional Radiology - Branch of the National Medical Research Radiological Centre of the Ministry of Health of Russian Federation
Russian Federation
Russian Federation
A. V. Kazachenko
N.A.Lopatkin Research Institute of Urology and Interventional Radiology - Branch of the National Medical Research Radiological Centre of the Ministry of Health of Russian Federation
Russian Federation
Russian Federation
A. A. Kalabekov
N.A.Lopatkin Research Institute of Urology and Interventional Radiology - Branch of the National Medical Research Radiological Centre of the Ministry of Health of Russian Federation
Russian Federation
Russian Federation
M. V. Grebenkin
N.A.Lopatkin Research Institute of Urology and Interventional Radiology - Branch of the National Medical Research Radiological Centre of the Ministry of Health of Russian Federation
Russian Federation
Russian Federation
S. A. Golovanov
N.A.Lopatkin Research Institute of Urology and Interventional Radiology - Branch of the National Medical Research Radiological Centre of the Ministry of Health of Russian Federation
Russian Federation
Russian Federation
V. V. Droggeva
N.A.Lopatkin Research Institute of Urology and Interventional Radiology - Branch of the National Medical Research Radiological Centre of the Ministry of Health of Russian Federation
Russian Federation
Russian Federation
References
1. Анохин П. К. Функциональная система как методологический принцип биологического и физиологического исследования. В кн.: Системная организация физиологических функций. М., 1968. С. 5-7.
2. Общая физиология функциональных систем организма / под ред. К.В. Судакова. М.: «Медицина», 1983. 272 с.
3. Судаков К. В. Общие закономерности системогенеза. В кн.: Теория системогенеза. М., 1997. С. 7-91.
4. Меерсон Ф.З. Патогенез и предупреждение стрессорных и ише- мических повреждений сердца. М.: Медицина, 1984. 272 с.
5. Аполихин О.И., Сивков А.В., Константинова О.В., Сломинский П.А., Тупицына Т.В., Калиниченко Д.Н. Генетические факторы риска рецидивного уролитиаза. Экспериментальная и клиническая урология 2016;(3):127-130.
6. Иващенко В.В. Механизм адаптогенного действия гипохлорита натрия при непрямом электрохимическом окислении крови и его применение в урологии. Дис.. д-ра мед. наук. М. 2016. 361 с.
7. Федоровский Н.М. Непрямая электрохимическая детоксикация: Пособие для последипломной подготовки врачей. М.: «Медицина», 2004. 144 с.
8. Харченко М.А. Корреляционный анализ (учебное пособие для вузов). Издательско-полиграфический центр Воронежского государственного университета, 2008. 30 с.
Review
For citations:
Ivashchenko V.V., Chernyshev I.V., Kirpatovsky V.I., Kazachenko A.V., Kalabekov A.A., Grebenkin M.V., Golovanov S.A., Droggeva V.V. CORTISOL AND ALDOSTERONE ARE THE RISK FACTORS OF UROLITHIASIS. Surgical practice (Russia). 2017;(3):46-54. (In Russ.)
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