CELLULAR AND MOLECULAR MECHANISMS OF STIMULATION OF THE SKIN AFTER IMPLANTATION OF THREADS BASED ON POLYDIOXANONE

Abstract

The article is devoted to assessment of cellular and molecular mechanisms of skin stimulation after implantation of polydioxanone threads.The aim of the study: assessment of polydioxanone threads impact on the skin biostimulation.Design: prospective, independent, placebo-controlled study.Materials and methods: the authors performed a prospective, independent, placebo-controlled clinical and morphological study in the period 2015-2017, that enrolled 22 volunteers (35-50 years old) with age associated skin changes. General morphological examination of skin bioptates was performed on slides stained with hematoxylin and eosin, and by van Gieson method. To assess different cell lines after polydioxanone treads implantation the immunohistochemistry was used.The results of study showed that polydioxanone treads stimulates several mechanisms of skin remodeling with activation of repair mechanisms. This process was manifested by angiogenesis through stimulation of VEGF expression and reorganization of the vascular bed of the skin and stimulation of the private reserve of fibroblasts lineage through the activation of the stromal vascular fraction. It should be noted that in addition to activation of neocollagenogenesis leading to the restructuring of the dermis and epidermis, polydioxanone threads implantation had a positive impact on the balance of MMP/TIMR, limiting degradation mechanisms and contributing to the accumulation matrix of the connective tissue of the dermis.Conclusion: Thus, polydioxanone treads have pleiotropic stimulating effect on the dermis remodelling.