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PARASITIC ABSCESS AS AN INCIDENTAL HISTOLOGICAL FINDING IN THE TREATMENT OF SIGMOID COLON CANCER

https://doi.org/10.38181/2223-2427-2020-3-53-58

Abstract

Background: A high worldwide incidence of colorectal cancer defines the importance of search not only for effective treatment methods, but also for risk factors for the cancer development and its worst prognosis. The influence of many genetic factors, environmental characteristics and lifestyle features has already been proven, and recently the attention of researchers is being focused on the study of microbiota and, in particular, various parasitic intestinal diseases in the context of risk factors for colorectal cancer.
Clinical case presentation: we demonstrate an incidental finding of parasitic invasion signs during the pathomorphological examination of the surgical specimen in a patient without an epidemiological history.
Conclusion: Further studies are needed not only to confirm and substantiate the role of micro- and macroorganisms inhabiting the intestine in the development of oncological diseases, but also to identify individual links of pathogenesis, pathological pathways and signaling molecules involved in carcinogenesis. Research like this could help broaden knowledge about both the risk factors and predictors of colorectal cancer and the potential sites for targeted therapy.

About the Authors

E. A. Galliamov
Federal State Budget Educational Institution of Higher Education M. V. Lomonosov Moscow State University (Lomonosov MSU); Federal State Autonomous Educational Institution of Higher Education I. M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Eduard A. Galliamov — MD, Professor, Head of the Department of General Surgery

Leninskie Gory St., 1, 119991, Moscow, Russian Federation

Bolshaya Pirogovskaya St., 19/1, 119146, Moscow, Russian Federation



M. A. Agapov
Federal State Budget Educational Institution of Higher Education M. V. Lomonosov Moscow State University (Lomonosov MSU)
Russian Federation

Mikhail A. Agapov — PhD, Professor at the Department of Surgery

Leninskie Gory St., 1, 119991, Moscow, Russian Federation



P. G. Mal’kov
Federal State Budget Educational Institution of Higher Education M. V. Lomonosov Moscow State University (Lomonosov MSU)
Russian Federation

Pavel G. Mal’kov — MD, Professor, Head of the Department of Clinical Patology of the Medical Research Educational Center

Leninskie Gory St., 1, 119991, Moscow, Russian Federation



D. R. Markaryan
Federal State Budget Educational Institution of Higher Education M. V. Lomonosov Moscow State University (Lomonosov MSU)
Russian Federation

Daniil R. Markaryan — PhD, Docent at the Department of Surgery

Leninskie Gory St., 1, 119991, Moscow, Russian Federation



N. V. Danilova
Federal State Budget Educational Institution of Higher Education M. V. Lomonosov Moscow State University (Lomonosov MSU)
Russian Federation

Natalya V. Danilova — PhD, Senior Researcher at the Department of Clinical Patology of the Medical Research Educational Center

Leninskie Gory St., 1, 119991, Moscow, Russian Federation



V. V. Kakotkin
Federal State Budget Educational Institution of Higher Education M. V. Lomonosov Moscow State University (Lomonosov MSU)
Russian Federation

Viktor V. Kakotkin — Surgeon at the Department of Surgery №1 of the Medical Research Educational Center

Leninskie Gory St., 1, 119991, Moscow, Russian Federation



E. A. Kazachenko
Federal State Budget Educational Institution of Higher Education M. V. Lomonosov Moscow State University (Lomonosov MSU)
Russian Federation

Ekaterina A. Kazachenko — Resident at the Department of Surgery of the Faculty of Medicine

Leninskie Gory St., 1, 119991, Moscow, Russian Federation



A. M. Lukyanov
Federal State Budget Educational Institution of Higher Education M. V. Lomonosov Moscow State University (Lomonosov MSU)
Russian Federation

Aleхander M. Lukyanov — Resident at the Department of Surgery of the Faculty of Medicine

Leninskie Gory St., 1, 119991, Moscow, Russian Federation



N. A. Oleynikova
Federal State Budget Educational Institution of Higher Education M. V. Lomonosov Moscow State University (Lomonosov MSU)
Russian Federation

Nina A. Oleynikova – PhD, Researcher of the Department of Clinical Pathology of the Medical Research Educational Center

Leninskie Gory St., 1, 119991, Moscow, Russian Federation



V. A. Kubyshkin
Federal State Budget Educational Institution of Higher Education M. V. Lomonosov Moscow State University (Lomonosov MSU)
Russian Federation

Valery A. Kubyshkin — PhD, academician at RSA, Head of the Surgery Department

Leninskie Gory St., 1, 119991, Moscow, Russian Federation



References

1. Wei Liu, Hong-Ze Zeng, Qi-Ming Wang, Hang Yi, Yi Mou, Chun-Cheng Wu, Bing Hu, Cheng-Wei Tang. Schistosomiasis combined with colorectal carcinoma diagnosed based on endoscopic findings and clinicopathological characteristics: A report on 32 cases. Asian Pacific J. Cancer Prev.14, 4839–4842 (2013). DOI: 10.7314/apjcp.2013.14.8.4839

2. H Salim, O. E., Hamid, H. K. S., Mekki, S. O., Suleiman, S. H. & Ibrahim, S. Z. Colorectal carcinoma associated with schistosomiasis: A possible causal relationship. World Journal of Surgical Oncology 8, 68 (2010). DOI: 10.1186/1477-7819-8-68

3. AM Herman, A Kishe, H Babu, H Shilanaiman, M Tarmohamed, J Lodhia, P Amsi, J Pyuza, A Mremi, A Mwasamwaja, M Nyindo, K Chilonga, D Msuya. Colorectal cancer in a patient with intestinal schistosomiasis: A case report from Kilimanjaro Christian Medical Center Northern Zone Tanzania. World J. Surg. Oncol.15, (2017).DOI: 10.1186/s12957-017-1217-1

4. RL Siegel, KD Miller, AG Sauer, SA Fedewa, LF Butterly, JC Anderson, A Cercek, RA Smith, A Jemal. Colorectal cancer statistics, 2020. A Cancer J Clin. 2020 May;70(3):145-164. doi: 10.3322/caac.21601

5. Hiroshi Asano, Kazuto Kojima, Naomi Ogino, Hiroyuki Fukano, Yasuhiro Ohara, Nozomi Shinozuka.Postoperative recurrence and risk factors of colorectal cancer perforation. Int. J. Colorectal Dis.32, 419–424 (2017). doi: 10.1007/s00384-016-2694-3

6. Peterson, M. R. & Weidner, N. Gastrointestinal neoplasia associated with bowel parasitosis: Real or imaginary? Journal of Tropical Medicine 2011, (2011).

7. Wang, X. & Huycke, M. M. Colorectal cancer: Role of commensal bacteria and bystander effects. Gut Microbes 6, 370–376 (2015). doi:10.1080/19490976.2015.1103426

8. Ya-Nan Yu, Ta-Chung Yu, Hui-Jun Zhao, Tian-Tian Sun, Hui-Min Chen, Hao-Yan Chen, Hui-Fang An, Yu-Rong Weng, Jun Yu, Min Li, Wen-Xin Qin, Xiong Ma, Nan Shen, Jie Hong, Jing-Yuan Fang. Berberine may rescue Fusobacterium nucleatum-induced colorectal tumorigenesis by modulating the tumor microenvironment. Oncotarget 6, 32013–32026 (2015). DOI:10.18632/oncotarget.5166

9. Márcia H Fukugaiti, Aline Ignacio, Miriam R Fernandes, Ulysses Ribeiro Júnior, Viviane Nakano, Mario J Avila-Campos. High occurrence of fusobacterium nucleatum and clostridium difficile in the intestinal microbiota of colorectal carcinoma patients. Brazilian J. Microbiol.46, 1135–1140 (2015).DOI: 10.1590/S1517-838246420140665

10. Landman, C. & Quévrain, E. Le microbiote intestinal : description, rôle et implication physiopathologique. Revue de Medecine Interne 37, 418–423 (2016).

11. Coleman, O. I. & Nunes, T. Role of the Microbiota in Colorectal Cancer: Updates on Microbial Associations and Therapeutic Implications. BioResearch Open Access 5, 279–288 (2016).

12. Abdurakhim Toychiev, Sulayman Abdujapparov, Alim Imamov, Behzod Navruzov, Nikolay Davis, Najiya Badalova, Svetlana Osipova. Intestinal helminths and protozoan infections in patients with colorectal cancer: prevalence and possible association with cancer pathogenesis. Parasitol. Res. 117, 3715–3723 (2018). DOI:10.1007/s00436-018-6070-9

13. Hamid, H. K. S. Review article schistosoma japonicum associated colorectal cancer: A review. American Journal of Tropical Medicine and Hygiene 100, 501–505 (2019).

14. Rosin, M. P., El Din Zaki, S. S., Ward, A. J. & Anwar, W. A. Involvement of inflammatory reactions and elevated cell proliferation in the development of bladder cancer in schistosomiasis patients. Mutat. Res. – Fundam. Mol. Mech. Mutagen.305, 283–292 (1994).DOI: 10.1016/0027-5107(94)90248-8

15. C Trakatelli, S Frydas, M Hatzistilianou, E Papadopoulos, I Simeonidou, A Founta, D Paludi, C Petrarca, M L Castellani, N Papaioannou, V Salini, P Conti, D Kempuraj, J Vecchiet. Chemokines as markers for parasite-induced inflammation and tumors. International Journal of Biological Markers 20, 197–203 (2005).DOI: 10.1177/172460080502000401

16. Mayer, D. A. & Fried, B. The Role of Helminth Infections in Carcinogenesis. Advances in Parasitology 65, 239–296 (2007).

17. Herrera, L. A., Benítez-Bribiesca, L., Mohar, A. & Ostrosky-Wegman, P. Role of infectious diseases in human carcinogenesis. Environmental and Molecular Mutagenesis 45, 284–303 (2005).

18. Quan Yang, Huaina Qiu, Hongyan Xie, Yanwei Qi, Hefei Cha, Jiale Qu, Mei Wang, Yuanfa Feng, Xin Ye, Jianbing Mu, Jun Huang. A Schistosoma japonicum Infection Promotes the Expansion of Myeloid-Derived Suppressor Cells by Activating the JAK/STAT3 Pathway . J. Immunol.198, 4716–4727 (2017).DOI: 10.4049/jimmunol.1601860

19. Maizels, R. M. & McSorley, H. J. Regulation of the host immune system by helminth parasites. J. Allergy Clin. Immunol.138, 666–675 (2016).

20. Nakamura, K., Kitani, A. & Strober, W. Cell contact-dependent immunosuppression by CD4+CD25+ regulatory T cells is mediated by cell surface-bound transforming growth factor β. J. Exp. Med. 194, 629–644 (2001).

21. Eleonora Timperi, Ilenia Pacella, Valeria Schinzari, Chiara Focaccetti, Luca Sacco, Francesco Farelli, Roberto Caronna, Gabriella Del Bene, Flavia Longo, Antonio Ciardi, Sergio Morelli, Anna Rita Vestri, Piero Chirletti, Vincenzo Barnaba, Silvia Piconese. Regulatory T cells with multiple suppressive and potentially pro-tumor activities accumulate in human colorectal cancer. Oncoimmunology 5, (2016).DOI: 10.1080/2162402X.2016.1175800

22. Morteza Motallebnezhad, Farhad Jadidi-Niaragh, Elmira Safaie Qamsari, Salman Bagheri, Tohid Gharibi, Mehdi Yousefi. The immunobiology of myeloid-derived suppressor cells in cancer. Tumor Biology 37, 1387–1406 (2016).DOI: 10.1007/ s13277-015-4477-9

23. Gabrilovich, D. I. & Nagaraj, S. Myeloid-derived suppressor cells as regulators of the immune system. Nature Reviews Immunology 9, 162–174 (2009).DOI: 10.1038/nri2506


Review

For citations:


Galliamov E.A., Agapov M.A., Mal’kov P.G., Markaryan D.R., Danilova N.V., Kakotkin V.V., Kazachenko E.A., Lukyanov A.M., Oleynikova N.A., Kubyshkin V.A. PARASITIC ABSCESS AS AN INCIDENTAL HISTOLOGICAL FINDING IN THE TREATMENT OF SIGMOID COLON CANCER. Surgical practice (Russia). 2020;(3):53-58. (In Russ.) https://doi.org/10.38181/2223-2427-2020-3-53-58

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