Prognosis of the risk of acute postresection liver failure in focal liver diseases

Aim. to determine the effect of the volume of resection and the etiology of the disease on the risk of developing acute postresection liver failure (APN).

Materials and methods. The study included 43 patients who underwent surgery for bulky liver tumors. The prognosis for the development of acute postresection liver failure was calculated for all patients. According to etiology, patients are divided into 3 clinical groups. Group I – patients with liver echinococcosis, group II – patients with malignant neoplasms and group III – with benign tumors. Depending on the volume of liver resection, two groups were identified – IV and V. The fourth group consisted of 23 patients with resection of 1-2 liver segments, and the fifth group consisted of 20 patients who had 3 or more liver segments removed.

Results. With resection of 1-2 liver segments (group IV), the percentage of acute renal failure, regardless of the etiology of the lesion, was about 4%. In patients of the fourth group, with the removal of 3 or more segments, the risk of developing OPN was statistically significantly higher in patients with malignant neoplasms. In patients with malignant liver damage, the probability of developing acute renal failure increases to 15%, while in patients with liver echinococcosis and benign neoplasms with resection of 3 or more liver segments, the probability of developing acute renal failure does not exceed 7%.

Conclusion. The probability of developing acute renal failure does not directly depend on the etiology of the disease. With resection of 1-2 liver segments, the risk of acute renal failure is minimal, regardless of the etiology of the disease. With resection of 3 or more segments, the probability of acute renal failure in patients with malignancies is higher. In patients with benign tumors and with liver echinococcosis, the probability of acute renal failure did not differ significantly.

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