THE ROLE OF INFLAMMATION MARKERS IN THE EARLY POSTOPERATIVE PERIOD FOR MANAGEMENT PATIENTS WITH COLORECTAL CANCER

Objective: To evaluate the role of inflammatory markers in the early diagnosis of complications of colorectal cancer surgical treatment.

Methods: the study was conducted in the Medical Research and Education Center of Moscow State University named after M.V. Lomonosov from 2019 to 2021. The study included all patients who underwent surgical treatment for colorectal cancer in the 1st surgical department of the Moscow Research and Educational Center, Lomonosov Moscow State University. M.V. Lomonosov. The study examined clinical and laboratory data based on case histories of patients with stage II-III colorectal cancer, who underwent elective colorectal cancer treatment with lymph node dissection with the formation of a primary anastomosis. All patients underwent routine proctography in the early postoperative period.

Results: The study included 80 patients with stage I-III colorectal cancer, of which 26 had septic complications, including clinically insignificant anastomosis leakage. Statistically significant differences was found between the groups of patient with and without septic complications on the 2nd day of the postoperative day in terms of the absolute level of leukocytes (p=0.01), hemoglobin (p=0.07), total protein (p=0.02) and C-reactive protein (p=0.03).

Conclusion: An increase in the level of markers of the inflammatory response, such as the number of leukocytes, the level of total protein and the level of C-reactive protein, can be observed already at a relatively early postoperative period in patients with infectious complications, including those with clinically insignificant intestinal anastomotic leaks.

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