<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">spractice</journal-id><journal-title-group><journal-title xml:lang="ru">Хирургическая практика</journal-title><trans-title-group xml:lang="en"><trans-title>Surgical practice (Russia)</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2223-2427</issn><publisher><publisher-name>АНО "Консорциум "Медицинская техника"</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.5922/2223-2427-2025-10-1-1</article-id><article-id custom-type="elpub" pub-id-type="custom">spractice-546</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group></article-categories><title-group><article-title>Эндоскопическая семиотика и диагностика нейроэндокринных опухолей прямой кишки</article-title><trans-title-group xml:lang="en"><trans-title>Endoscopic semiotics and diagnostics of rectal neuroendocrine tumors</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0005-7048-5669</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Вишневский</surname><given-names>А. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Vishnevskii</surname><given-names>A. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Александр Станиславович Вишневский – врач-эндоскопист</p><p>115522, Москва, Каширское шоссе, 24</p></bio><bio xml:lang="en"><p>Alexander S. Vishnevskii – Endoscopist</p><p>Kashirskoye highway, 24, Moscow, 115522</p></bio><email xlink:type="simple">vishnevskiy2405@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Карасев</surname><given-names>И. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Karasev</surname><given-names>I. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Иван Александрович Карасев – кандидат медицинских наук, старший научный сотрудник, и.о. заведующего эндоскопическим отделением</p><p>115522, Москва, Каширское шоссе, 24</p></bio><bio xml:lang="en"><p>Ivan A. Karasev – Associate professor, Senior researcher, Head of the Endoscopic department</p><p>Kashirskoye highway, 24, Moscow, 115522</p></bio><email xlink:type="simple">ronc-karasev@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1787-1019</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Давыдкина</surname><given-names>Т. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Davydkina</surname><given-names>T. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Татьяна Сергеевна Давыдкина – врач-эндоскопист</p><p>115522, Москва, Каширское шоссе, 24</p></bio><bio xml:lang="en"><p>Tatiana S. Davydkina – Endoscopist</p><p>Kashirskoye highway, 24, Moscow, 115522</p></bio><email xlink:type="simple">davydkinatanya@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0868-3948</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Крыловецкая</surname><given-names>М. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Krylovetskaya</surname><given-names>M. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мария Александровна Крыловецкая – кандидат медицинских наук, врач-эндоскопист</p><p>115522, Москва, Каширское шоссе, 24</p></bio><bio xml:lang="en"><p>Maria A. Krylovetskaya – Associate professor</p><p>Kashirskoye highway, 24, Moscow, 115522</p></bio><email xlink:type="simple">mariyakrilo@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3495-5521</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Комаров</surname><given-names>И. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Komarov</surname><given-names>I. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Игорь Геннадьевич Комаров – доктор медицинских наук, ведущий научный сотрудник</p><p>115522, Москва, Каширское шоссе, 24</p></bio><bio xml:lang="en"><p>Igor G. Komarov – Professor, Leading Researcher</p><p>Kashirskoye highway, 24, Moscow, 115522</p></bio><email xlink:type="simple">komaroving@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Национальный медицинский исследовательский центр онкологии имени Н.Н. Блохина</institution><country>Россия</country></aff><aff xml:lang="en"><institution>N.N. Blokhin National Medical Research Center of Oncology</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>17</day><month>05</month><year>2025</year></pub-date><volume>0</volume><issue>1</issue><fpage>3</fpage><lpage>11</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Вишневский А.С., Карасев И.А., Давыдкина Т.С., Крыловецкая М.А., Комаров И.Г., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Вишневский А.С., Карасев И.А., Давыдкина Т.С., Крыловецкая М.А., Комаров И.Г.</copyright-holder><copyright-holder xml:lang="en">Vishnevskii A.S., Karasev I.A., Davydkina T.S., Krylovetskaya M.A., Komarov I.G.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.spractice.ru/jour/article/view/546">https://www.spractice.ru/jour/article/view/546</self-uri><abstract><sec><title>Цель</title><p>Цель. Оценить роль эндоскопических методик в диагностике нейроэндокринных опухолейпрямой кишки, а также определить особенности и признаки характерные для этих новообразований.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. Проведён анализ 28 пациентов с нейроэндокринными опухолямипрямой кишки, обследованных в НМИЦ онкологии им. Н.Н. Блохина за последние полторагода. Установлены следующие данные: средний размер образований, наиболее частая ихлокализация, средний индекс пролиферации и предпочтительный метод лечения.</p></sec><sec><title>Результаты</title><p>Результаты. Средний период наблюдения составил 25 месяцев. Медиана возраста составила 47,5 лет. Всем пациентам была выполнена колоноскопия с применением уточняющихметодик диагностики. В 57% случаев опухоли локализовались в среднеампулярном отделепрямой кишки, в 32 % – в нижнеампулярном отделе и в 11 % – в верхнеампулярном отделе.Средний размер образований составлял 9 мм. По результатам гистологического исследования в 73 % случаев выявлен 1 тип по классификации ВОЗ, а в 27% – 2 тип. Всем пациентамбыло проведено хирургическое лечение. Признаков прогрессирования заболевания на момент оценки результатов не выявлено.</p></sec><sec><title>Заключение</title><p>Заключение. Согласно последним данным, в настоящее время не существует единой тактики ведения пациентов с нейроэндокринными опухолями, а существующий план диагностики и лечения представляет собой мультидисциплинарный комплексный подход. Выбор адекватного объема оперативного вмешательства зависит от правильной эндоскопической оценки опухоли, позволяющей заподозрить нейроэндокринную природу образования до момента его удаления. Широкое внедрение колоноскопии, как метода скрининга, позволяет увеличить частоту выявляемости таких редких образований, как нейроэндокринные опухоли толстой кишки, а также повысить осведомленность врачей-эндоскопистов в распознавании нейроэндокринных опухолей прямой кишки.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Aim</title><p>Aim. To evaluate the role of endoscopic techniques in the diagnosis of neuroendocrine tumors of the rectum, as well as to determine the features and symptoms characteristic of these tumors.</p></sec><sec><title>Methods</title><p>Methods. An analysis of patients diagnosed with R-NETs examined at the N.N. Blokhin NationalMedical Research Center of Oncology over the past year and a half was conducted. The followingdata were established: the average size of the formations, their most common localization, theaverage proliferation index and the preferred method of treatment.</p></sec><sec><title>Results</title><p>Results. The average follow-up period was 25 months. The median age was 47,5 years. All patientsunderwent colonoscopy using clarifying diagnostic techniques. In 57% of cases, tumors were localized in the middle ampullary section of the rectum, in 32% in the lower ampullary section, andin 11% in the upper ampullary section. The average size of the formations was 9 mm.According tothe results of histological examination, type 1 according to the WHO classification was identified in73% of cases, and type 2 in 27% of cases. All patients underwent surgical treatment. There wereno signs of disease progression at the time of evaluation of the results.</p></sec><sec><title>Conclusion</title><p>Conclusion. According to the latest data, there is currently no single tactic for managing patients with neuroendocrine tumors, and the existing diagnostic and treatment plan is a multidisciplinary comprehensive approach. The choice of an adequate volume of surgical intervention depends on the correct endoscopic assessment of the tumor, which allows suspecting the neuroendocrine nature of the formation before its removal. The widespread introduction of colonoscopy as a screening method allows increasing the detection rate of such rare formations as neuroendocrine tumors of the colon, as well as increasing the awareness of endoscopists in recognizing neuroendocrine tumors of the rectum.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>нейроэндокринные опухоли</kwd><kwd>прямая кишка</kwd><kwd>эндоскопия</kwd><kwd>опухоли прямой кишки</kwd><kwd>колоноскопия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>neuroendocrine tumors</kwd><kwd>rectum</kwd><kwd>endoscopy</kwd><kwd>rectal neuroendocrine tumors</kwd><kwd>colonoscopy</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Lawrence B, Gustafsson BI, Chan A, Svejda B, Kidd M, Modlin IM. The epidemiology of gastroenteropancreatic neuroendocrine tumors. Endocrinol Metab Clin North Am. 2011;40(1):1–18. https://doi.org/10.1016/j.ecl.2010.12.005</mixed-citation><mixed-citation xml:lang="en">Lawrence B, Gustafsson BI, Chan A, Svejda B, Kidd M, Modlin IM. The epidemiology of gastroenteropancreatic neuroendocrine tumors. Endocrinol Metab Clin North Am. 2011;40(1):1–18. https://doi.org/10.1016/j.ecl.2010.12.005</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Huguet I, Grossman AB, O’Toole D. Changes in the Epidemiology of Neuroendocrine Tumours. Neuroendocrinology. 2017;104(2):105-111. https://doi.org/10.1159/000441897</mixed-citation><mixed-citation xml:lang="en">Huguet I, Grossman AB, O’Toole D. Changes in the Epidemiology of Neuroendocrine Tumours. Neuroendocrinology. 2017;104(2):105-111. https://doi.org/10.1159/000441897</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Мамедов И.Я., Фейдоров И.Ю. Эпидемиология нейроэндокринных опухолей на примере регистра московского клинического научного центра им. А.С. Логинова. Эндокринная хирургия. 2023;17(4):56. https://doi.org/10.14341/serg12879</mixed-citation><mixed-citation xml:lang="en">Mamedov I.Ya., Feydorov I.Yu. Epidemiology of neuroendocrine tumors on the example of the registry of the Moscow Clinical Research Center named after A.S. Loginov. Endocrine Surgery. 2023;17(4):56. (In Russ.) https://doi.org/10.14341/serg12879</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Dasari A, Shen C, Halperin D, Zhao B, Zhou S, Xu Y, Shih T, Yao JC. Trends in the Incidence, Prevalence, and Survival Outcomes in Patients With Neuroendocrine Tumors in the United States. JAMA Oncol. 2017 Oct 1;3(10):1335-1342. https://doi.org/10.1001/jamaoncol.2017.0589</mixed-citation><mixed-citation xml:lang="en">Dasari A, Shen C, Halperin D, Zhao B, Zhou S, Xu Y, Shih T, Yao JC. Trends in the Incidence, Prevalence, and Survival Outcomes in Patients With Neuroendocrine Tumors in the United States. JAMA Oncol. 2017 Oct 1;3(10):1335-1342. https://doi.org/10.1001/jamaoncol.2017.0589</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Ellis L, Shale MJ, Coleman MP. Carcinoid tumors of the gastrointestinal tract: trends in incidence in England since 1971. Am J Gastroenterol. 2010 Dec;105(12):2563-9. Epub 2010 Sep 7. https://doi.org/10.1038/ajg.2010.341.</mixed-citation><mixed-citation xml:lang="en">Ellis L, Shale MJ, Coleman MP. Carcinoid tumors of the gastrointestinal tract: trends in incidence in England since 1971. Am J Gastroenterol. 2010 Dec;105(12):2563-9. Epub 2010 Sep 7. https://doi.org/10.1038/ajg.2010.341.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Hauso O, Gustafsson BI, Kidd M, Waldum HL, Drozdov I, Chan AK, Modlin IM. Neuroendocrine tumor epidemiology: contrasting Norway and North America. Cancer. 2008 Nov 15;113(10):2655-64. PMID: 18853416. https://doi.org/10.1002/cncr.23883</mixed-citation><mixed-citation xml:lang="en">Hauso O, Gustafsson BI, Kidd M, Waldum HL, Drozdov I, Chan AK, Modlin IM. Neuroendocrine tumor epidemiology: contrasting Norway and North America. Cancer. 2008 Nov 15;113(10):2655-64. PMID: 18853416. https://doi.org/10.1002/cncr.23883</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Yao JC, Hassan M, Phan A, Dagohoy C, Leary C, Mares JE, Abdalla EK, Fleming JB, Vauthey JN, Rashid A, Evans DB. One hundred years after “carcinoid”: epidemiology of and prognostic factors for neuroendocrine tumors in 35,825 cases in the United States. J Clin Oncol. 2008 Jun 20;26(18):3063-72. https://doi.org/10.1200/JCO.2007.15.4377</mixed-citation><mixed-citation xml:lang="en">Yao JC, Hassan M, Phan A, Dagohoy C, Leary C, Mares JE, Abdalla EK, Fleming JB, Vauthey JN, Rashid A, Evans DB. One hundred years after “carcinoid”: epidemiology of and prognostic factors for neuroendocrine tumors in 35,825 cases in the United States. J Clin Oncol. 2008 Jun 20;26(18):3063-72. https://doi.org/10.1200/JCO.2007.15.4377</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Kwaan M R, Goldberg J E, Bleday R. Rectal carcinoid tumors: review of results after endoscopic and surgical therapy. Arch Surg. 2008;143(5):471–475. https://doi.org/10.1001/archsurg.143.5.471</mixed-citation><mixed-citation xml:lang="en">Kwaan M R, Goldberg J E, Bleday R. Rectal carcinoid tumors: review of results after endoscopic and surgical therapy. Arch Surg. 2008;143(5):471–475. https://doi.org/10.1001/archsurg.143.5.471</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Cope J, Srirajaskanthan R. Rectal Neuroendocrine Neoplasms: Why Is There a Global Variation? Curr Oncol Rep. 2022 Mar;24(3):257-263. Epub 2022 Jan 27. https://doi.org/10.1007/s11912-021-01172-1</mixed-citation><mixed-citation xml:lang="en">Cope J, Srirajaskanthan R. Rectal Neuroendocrine Neoplasms: Why Is There a Global Variation? Curr Oncol Rep. 2022 Mar;24(3):257-263. Epub 2022 Jan 27. https://doi.org/10.1007/s11912-021-01172-1</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Basuroy R, Haji A, Ramage JK, Quaglia A, Srirajaskanthan R. Review article: the investigation and management of rectal neuroendocrine tumours. Aliment Pharmacol Ther. 2016;44(4):332–345. https://doi.org/10.1111/apt.13697</mixed-citation><mixed-citation xml:lang="en">Basuroy R, Haji A, Ramage JK, Quaglia A, Srirajaskanthan R. Review article: the investigation and management of rectal neuroendocrine tumours. Aliment Pharmacol Ther. 2016;44(4):332–345. https://doi.org/10.1111/apt.13697</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Hallet J, Law CHL, Cukier M, Saskin R, Liu N, Singh S. Exploring the rising incidence of neuroendocrine tumors: a population-based analysis of epidemiology, metastatic presentation, and outcomes. Cancer. 2015;121(4):589–597. https://doi.org/10.1002/cncr.29099</mixed-citation><mixed-citation xml:lang="en">Hallet J, Law CHL, Cukier M, Saskin R, Liu N, Singh S. Exploring the rising incidence of neuroendocrine tumors: a population-based analysis of epidemiology, metastatic presentation, and outcomes. Cancer. 2015;121(4):589–597. https://doi.org/10.1002/cncr.29099</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
