spracticeХирургическая практикаSurgical practice (Russia)2223-2427АНО "Консорциум "Медицинская техника"10.5922/2223-2427-2024-9-3-5spractice-493Research ArticleОБЗОРЫ ЛИТЕРАТУРЫСовременные представления о роли тромбоцитарных факторов в стимуляции регенерации ранNew perspectives on the role of platelet factors in enhancing wound regenerationhttps://orcid.org/0000-0002-1350-0704СупильниковА. А.SupilnikovA. A.

Алексей Александрович Супильников, кандидат медицинских наук, доцент, первый проректор по научной деятельности

443001, Самара, ул. Чапаевская, 227

Alexey A. Supilnikov, Associate Professor

227, Chapaevskaya St., Samara, 44300

a_supilnikov@mail.ruhttps://orcid.org/0000-0002-9657-8063СергеевА. Н.SergeevA. N.

Алексей Николаевич Сергеев, доктор медицинских наук, доцент, заведующий кафедрой общей хирургии

170100, Тверь, ул. Советская, 4

Alexey N. Sergeev, Associate Professor, Head of the Department of General Surgery

4, Sovetskaya St., Tver, 170100

dr.nikolaevich@mail.ruhttps://orcid.org/0000-0003-4213-5379МорозовА. М.MorozovA. M.

Артем Михайлович Морозов, кандидат медицинских наук, доцент, доцент кафедры общей хирургии

170100, Тверь, ул. Советская, 4

Artem M. Morozov, Associate Professor, Associate Professor of the Department of General Surgery

4, Sovetskaya St., Tver, 170100

ammorozovv@gmail.comhttps://orcid.org/0000-0002-0241-1298АносоваЕ. Ю.AnosovE. Y.

Екатерина Юрьевна Аносова, хирург

129090, Москва, Большая Сухаревская площадь, 3

Ekaterina Yu. Anosova, Surgeon

3, Bolshaya Sukharevskaya Square, Moscow, 129090

anosova.kate@gmail.comhttps://orcid.org/0000-0001-5889-8675ЯреминБ. И.YareminB. I.

Борис Иванович Яремин, ведущий специалист отдела внешних научных связей, доцент кафедры трансплантологии и искусственных органов, заведующий кафедрой хирургических болезней, кандидат медицинских наук, врач-хирург

443001, Самара, ул. Чапаевская, 227

129090, Москва, Большая Сухаревская площадь, 3

Boris I. Yaremin, Surgeon, Leading specialist of the Department of External Scientific Relations; Associate Professor of the Department of Transplantology and Artificial Organs; Head of the Department of Surgical Diseases

227, Chapaevskaya St., Samara, 44300

3, Bolshaya Sukharevskaya Square, Moscow, 129090

b.i.yaremin@reaviz.onlineШтыреваП. А.ShtyrevaP. A.

Полина Алексеевна Штырева, студентка

127006,  Москва, ул. Долгоруковская, 4

Polina A. Shtyreva, Student of the Medical Faculty

4, Dolgorukovskaya St., Moscow, 127006

ammorozovv@gmail.comМедицинский университет «Реавиз»РоссияReaviz Medical UniversityRussian FederationТверской государственный медицинский университетРоссияTver State Medical UniversityRussian FederationНаучно-исследовательский институт скорой медицинской помощи имени Н. В. СклифосовскогоРоссияN. A. Sklifosovsky Research Institute of Emergency MedicineRussian FederationМедицинский университет «Реавиз»; Научно-исследовательский институт скорой медицинской помощи имени Н. В. СклифосовскогоРоссияReaviz Medical University; N. A. Sklifosovsky Research Institute of Emergency MedicineRussian FederationРоссийский университет медициныРоссияRussian University of MedicineRussian Federation202418092024034759Copyright © Супильников А.А., Сергеев А.Н., Морозов А.М., Аносова Е.Ю., Яремин Б.И., Штырева П.А., 20242024Супильников А.А., Сергеев А.Н., Морозов А.М., Аносова Е.Ю., Яремин Б.И., Штырева П.А.Supilnikov A.A., Sergeev A.N., Morozov A.M., Anosov E.Y., Yaremin B.I., Shtyreva P.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.spractice.ru/jour/article/view/493

Цель. Проанализировать применение биологических факторов в стимуляции процесса заживления ран. В ходе исследования был проведен анализ актуальных отечественных и зарубежных литературных источников по заданной теме.Материалы и методы. Анализ информационных источников проводился по ключевому запросу «Роль биологических факторов в стимуляции раневого процесса» на базе поисковых систем eLibrary и PubMed.Результаты. В настоящее время арсенал применяемых средств широк и разнообразен, используют как традиционные, так и экспериментальные методы: усовершенствованные повязки, тканевые матрицы, факторы роста (ФР), клеточную терапию и нанотехнологии. В процессе заживления ран несколько межклеточных, внутриклеточных и внеклеточных сигнальных механизмов регулируют различные фазы заживления.Заключение. Применение тромбоцитов в разных областях медицины дало многообещающие результаты при определенных заболеваниях, таких как острые и хронические повреждения костей и хрящей. Тем не менее до настоящего времени препараты на основе тромбоцитов не нашли широкого клинического применения. Ряд исследований доказывает участие тромбоцитов и связанных с ними продуктов — PMPs и экзосом — в различных фазах заживления ран. Наличие в тромбоцитарных гранулах большого количества биологически активных молекул, обладающих противовоспалительными, ангиогенными, пролиферативными и другими свойствами, делает тромбоциты привлекательными для использования в регенеративной медицине, в том числе для стимуляции заживления ран

Aim. To analyze the use of biological factors in the stimulation of the wound healing process. In the course of the study, we analysed relevant domestic and foreign literature sources on the given topic.Methods. The literature was reviewed using the key query ‘the role of biological factors in wound healing stimulation’ through the eLIBRARY and PubMed databases.Results. Currently, the range of therapeutic approaches is broad and diverse, incorporating both traditional and experimental methods such as advanced dressings, tissue matrices, growth factors (GFs), cell therapy, and nanotechnology. The wound healing process is regulated by a complex interplay of intercellular, intracellular, and extracellular signalling mechanisms across various phases of healing.Conclusion. The application of platelet-based therapies in different medical fields has shown promising outcomes in certain conditions, such as acute and chronic injuries of bone and cartilage. However, platelet-based preparations have yet to gain widespread clinical use. Several studies have demonstrated the involvement of platelets and related products, such as platelet microparticles (PMPs) and exosomes, in multiple phases of wound healing. The presence of a substantial number of biologically active molecules within platelet granules—exhibiting anti-inflammatory, angiogenic, proliferative, and other properties—renders platelets particularly attractive for use in regenerative medicine, including the stimulation of wound healin

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The authors declare that there are no conflicts of interest present.