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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">spractice</journal-id><journal-title-group><journal-title xml:lang="ru">Хирургическая практика</journal-title><trans-title-group xml:lang="en"><trans-title>Surgical practice (Russia)</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2223-2427</issn><publisher><publisher-name>АНО "Консорциум "Медицинская техника"</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.5922/2223-2427-2024-9-2-5</article-id><article-id custom-type="elpub" pub-id-type="custom">spractice-473</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ ЛИТЕРАТУРЫ</subject></subj-group></article-categories><title-group><article-title>Экспериментальное и клиническое обоснование применения стволовых жировых клеток в современной медицине</article-title><trans-title-group xml:lang="en"><trans-title>Advancements and Applications of Adipose-Derived Stem Cells in Modern Medicine: A Comprehensive Review</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3681-4685</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пахомова</surname><given-names>Р. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Pakhomova</surname><given-names>R. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Регина Александровна Пахомова, доктор медицинских наук, доцент, заведующая кафедрой пластической хирургии</p><p>125080, Москва, Волоколамское шоссе, 11</p></bio><bio xml:lang="en"><p>Regina A. Pakhomova, Associate Professor, Head of the Department of Plastic Surgery</p><p>11 Volokolamskoye Shosse, Moscow, 125080</p></bio><email xlink:type="simple">PRA5555@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8995-2862</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Винник</surname><given-names>Ю. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Vinnik</surname><given-names>Y. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Юрий Семенович Винник, доктор медицинских наук, профессор, заведующий кафедрой общей хирургии имени профессора М. И. Гульмана</p><p>660022, Красноярск, ул. Партизана Железняка, 1</p></bio><bio xml:lang="en"><p>Yuri S. Vinnik, Professor, Head of the Department of General Surgery named after Professor M. I. Gulman</p><p>1 Partizan Zheleznyak St., Krasnoyarsk, 660022</p></bio><email xlink:type="simple">yuvinnik@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5784-7067</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кочетова</surname><given-names>Л. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kochetova</surname><given-names>L. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Людмила Викторовна Кочетова, кандидат медицинских наук, доцент, профессор кафедры общей хирургии имени профессора М. И. Гульмана</p><p>660022, Красноярск, ул. Партизана Железняка, 1</p></bio><bio xml:lang="en"><p>Lyudmila V. Kochetova, Associate Professor, Professor of the Department of General Surgery named after Professor M. I. Gulman</p><p>1 Partizan Zheleznyak St., Krasnoyarsk, 660022</p></bio><email xlink:type="simple">DissovetKrasGMU@bk.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5112-9686</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бабаджанян</surname><given-names>А. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Babajanyan</surname><given-names>A. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Акоп Манасович Бабаджанян, ассистент кафедры общей хирургии имени профессора М. И. Гульмана</p><p>660022, Красноярск, ул. Партизана Железняка, 1</p></bio><bio xml:lang="en"><p>Akop M. Babadzhanyan, Assistant of the Department of General Surgery named after Prof. M. I. Gulman</p><p>Partizan Zheleznyak St., Krasnoyarsk, 660022</p></bio><email xlink:type="simple">Akop-b@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кашинцев</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Kashintsev</surname><given-names>V. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Вадим Алексеевич Кашинцев, студент 4-го курса</p><p>660022, Красноярск, ул. Партизана Железняка, 1</p></bio><bio xml:lang="en"><p>Vadim A. Kashintsev, Student</p><p>1 Partizan Zheleznyak St., Krasnoyarsk, 660022</p></bio><email xlink:type="simple">Kashincev.va@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0000-6089-8340</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кузьменко</surname><given-names>Д. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Kuzmenko</surname><given-names>D. P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Дарья Павловна Кузьменко, студентка 4-го курса</p><p>660022, Красноярск, ул. Партизана Железняка, 1</p></bio><bio xml:lang="en"><p>Daria P. Kuzmenko, Student</p><p>1 Partizan Zheleznyak St., Krasnoyarsk, 660022</p></bio><email xlink:type="simple">kuzya4517@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Российский биотехнологический университет (РОСБИОТЕХ)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Russian Biotechnological University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Красноярский государственный медицинский университет имени профессора В. Ф. Войно-Ясенецкого</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Professor V. F. Voino-Yasenetsky Krasnoyarsk State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>16</day><month>07</month><year>2024</year></pub-date><volume>0</volume><issue>2</issue><fpage>69</fpage><lpage>79</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Пахомова Р.А., Винник Ю.С., Кочетова Л.В., Бабаджанян А.М., Кашинцев В.А., Кузьменко Д.П., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Пахомова Р.А., Винник Ю.С., Кочетова Л.В., Бабаджанян А.М., Кашинцев В.А., Кузьменко Д.П.</copyright-holder><copyright-holder xml:lang="en">Pakhomova R.A., Vinnik Y.S., Kochetova L.V., Babajanyan A.M., Kashintsev V.A., Kuzmenko D.P.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.spractice.ru/jour/article/view/473">https://www.spractice.ru/jour/article/view/473</self-uri><abstract><p>В литературном обзоре рассматривается важная роль в современной медицине стволовых жировых клеток (ASCs) как сегмента мезенхимальных стволовых клеток. ASCs обладают уникальными характеристиками, такими как высокая способность к дифференцировке и регенерации, что делает их ценным ресурсом в области регенеративной медицины и терапии. Основное внимание уделяется методам изоляции и культивирования ASCs, необходимости соблюдения стандартов контроля за процессами культивирования и хранения стволовых клеток. Описаны молекулярные и клеточные характеристики, позволяющие использовать ASCs в различных сферах медицины, включая лечение кардиоваскулярных, неврологических расстройств, в реконструктивной хирургии и тканевой инженерии. Способность ASCs дифференцироваться в различные типы клеток, в том числе остеоциты, адипоциты, нейтральные клетки, эндотелиальные клетки сосудов, кардиомиоциты, делает перспективным применение этих клеток при лечении широкого круга заболеваний.Обзор затрагивает важные вопросы безопасности и этики, связанные с использованием ASCs, особенно в контексте их взаимодействия с опухолевыми клетками. Подчеркивается необходимость дальнейшего глубокого и мультидисциплинарного изучения взаимодействия ASCs с клетками «хозяина» для безопасного и полноценного применения их потенциала в клинической практике.Продемонстрирована возможность использования ASCs при лечении длительно незаживающих диабетических язв и ран за счет увеличения эпителизации и ускорения процессов образования грануляционной ткани. Показана их способность сокращать количество фибробластов в гипертрофированных рубцах.В заключение обзор подчеркивает значимость ASCs как одного из наиболее перспективных направлений в современной биомедицине и регенеративной медицине. Отмечается, что дальнейшие исследования этих клеток могут открыть новые подходы к лечению и предотвращению многих заболеваний.</p></abstract><trans-abstract xml:lang="en"><p>The literature review examines the significant role of adipose-derived stem cells (ASCs) as a segment of mesenchymal stem cells in modern medicine. ASCs possess unique characteristics, such as a high ability to differentiate and regenerate, making them a valuable resource in regenerative medicine and therapy. The review focuses on methods for isolating and cultivating ASCs and emphasizes the importance of adhering to standards for monitoring the cultivation and storage processes of stem cells. The molecular and cellular characteristics that enable the use of ASCs in various medical fields, including the treatment of cardiovascular and neurological disorders, reconstructive surgery, and tissue engineering, are described. The ability of ASCs to differentiate into diverse cell types, including osteocytes, adipocytes, neural cells, vascular endothelial cells, and cardiomyocytes, underscores their potential in treating a wide range of diseases.The review addresses critical ethical and safety considerations related to the use of ASCs, particularly their interaction with tumor cells. It emphasizes the need for further in-depth, multidisciplinary studies of ASC interactions with host cells to ensure their safe and effective use in clinical practice. Evidence is presented for the potential of ASCs in treating long-term non-healing diabetic ulcers and wounds by enhancing epithelialization and accelerating granulation tissue formation. Additionally, their ability to reduce the number of fibroblasts in hypertrophied scars is highlighted.In conclusion, the review underscores the significance of ASCs as one of the most promising areas in modern biomedicine and regenerative medicine. It notes that further research on these cells may lead to new approaches in the treatment and prevention of various diseases.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>стволовые жировые клетки (ASCs)</kwd><kwd>регенеративная медицина</kwd><kwd>мезенхимальные стволовые клетки</kwd><kwd>тканевая инженерия</kwd><kwd>клеточная терапия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>fat stem cells (ASCs)</kwd><kwd>regenerative medicine</kwd><kwd>mesenchymal stem cells</kwd><kwd>tissue engineering</kwd><kwd>cell therapy</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Si Z, Wang X, Sun C, Kang Y, Xu J, Wang X, Hui Y. Adipose-derived stem cells: Sources, potency, and implications for regenerative therapies. 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