<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">spractice</journal-id><journal-title-group><journal-title xml:lang="ru">Хирургическая практика</journal-title><trans-title-group xml:lang="en"><trans-title>Surgical practice (Russia)</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2223-2427</issn><publisher><publisher-name>АНО "Консорциум "Медицинская техника"</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.38181/2223-2427-2023-1-7</article-id><article-id custom-type="elpub" pub-id-type="custom">spractice-389</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ТРАВМАТОЛОГИЯ И ОРТОПЕДИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>TRAUMATOLOGY AND ORTHOPEDICS</subject></subj-group></article-categories><title-group><article-title>Артрофиброз локтевого сустава: механизмы и факторы развития</article-title><trans-title-group xml:lang="en"><trans-title>Arthrofibrosis of the elbow joint: mechanisms and factors of development</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6680-9334</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Егиазарян</surname><given-names>К. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Egiazaryan</surname><given-names>K. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Егиазарян Карен Альбертович - доктор медицинских наук, профессор, заведующий кафедрой травматологии, ортопедии и военно-полевой хирургии.</p><p>117997, Москва, ул. Островитянова, 1</p></bio><bio xml:lang="en"><p>Karen A. Egiazaryan – Prof., Pirogov Russian National Research Medical University.</p><p>Ostrovitianov St. 1, Moscow, 117997</p></bio><email xlink:type="simple">egkar@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3375-9879</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лазишвили</surname><given-names>Г. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Lazishvili</surname><given-names>G. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Лазишвили Гурам Давидович - доктор медицинских наук, профессор кафедры травматологии, ортопедии и военно-полевой хирургии.</p><p>117997, Москва, ул. Островитянова, 1</p></bio><bio xml:lang="en"><p>Guram D. Lazishvili - Prof., Pirogov Russian National Research Medical University.</p><p>Ostrovitianov St. 1, Moscow, 117997</p></bio><email xlink:type="simple">guramlaz@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6559-4263</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ратьев</surname><given-names>А. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Ratyev</surname><given-names>A. P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ратьев Андрей Петрович - доктор медицинских наук, профессор кафедры травматологии, ортопедии и военно-полевой хирургии.</p><p>117997, Москва, ул. Островитянова, 1</p></bio><bio xml:lang="en"><p>Andrey P. Ratyev – Prof., Pirogov Russian National Research Medical University.</p><p>Ostrovitianov St. 1, Moscow, 117997</p></bio><email xlink:type="simple">anratiev@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3497-5933</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бадриев</surname><given-names>Д. A.</given-names></name><name name-style="western" xml:lang="en"><surname>Badriev</surname><given-names>D. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Бадриев Денис Айдарович - ассистент кафедры травматологии, ортопедии и военно-полевой хирургии.</p><p>117997, Москва, ул. Островитянова, 1</p></bio><bio xml:lang="en"><p>Denis A. Badriev - Department of Traumatology, Orthopedics and Military Field Surgery, Pirogov Russian National Research Medical University.</p><p>Ostrovitianov St. 1, Moscow, 117997.</p></bio><email xlink:type="simple">ill1dan@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2486-225X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Жаворонков</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Zhavoronkov</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Жаворонков Евгений Александрович - кандидат медицинских наук, доцент кафедры травматологии, ортопедии и военно-полевой хирургии.</p><p>117997, Москва, ул. Островитянова, 1</p></bio><bio xml:lang="en"><p>Evgenij A. Zhavoronkov – Dr., Pirogov Russian National Research Medical University.</p><p>Ostrovitianov St. 1, Moscow, 117997</p></bio><email xlink:type="simple">ezhavoronkov@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1246-7578</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лидяев</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Lidyaev</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Лидяев Антон Анатольевич - ассистент кафедры травматологии, ортопедии и военно-полевой хирургии.</p><p>117997, Москва, ул. Островитянова, 1</p></bio><bio xml:lang="en"><p>Anton A. Lidyaev.</p><p>Ostrovitianov St. 1, Moscow, 117997</p></bio><email xlink:type="simple">dr.lidyaev@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Российский национальный исследовательский медицинский университет имени Н.И. Пирогова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Pirogov Russian National Research Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>03</day><month>05</month><year>2023</year></pub-date><volume>0</volume><issue>1</issue><fpage>81</fpage><lpage>97</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Егиазарян К.А., Лазишвили Г.Д., Ратьев А.П., Бадриев Д.A., Жаворонков Е.А., Лидяев А.А., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Егиазарян К.А., Лазишвили Г.Д., Ратьев А.П., Бадриев Д.A., Жаворонков Е.А., Лидяев А.А.</copyright-holder><copyright-holder xml:lang="en">Egiazaryan K.A., Lazishvili G.D., Ratyev A.P., Badriev D.A., Zhavoronkov E.A., Lidyaev A.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.spractice.ru/jour/article/view/389">https://www.spractice.ru/jour/article/view/389</self-uri><abstract><p>Дегенеративные заболевания, в основе которых лежит избыточное образование фиброзной ткани, являются распространенной и комплексной проблемой: выраженные и зачастую необратимые изменения приводят к нарушениям функции пораженного органа. Остеоартроз, остеоартрит, артрофиброз — патологические состояния, характеризующиеся хроническим воспалением и избыточной пролиферацией соединительной ткани. Локтевой сустав как наиболее мобильный и анатомически стабильный сустав человека подвержен артрофиброзу и значительному функциональному нарушению, что значительно снижает качество жизни пациента и обусловливает высокую социальную актуальность проблемы. Понимание механизмов развития артрофиброза позволяет определить наиболее эффективные точки приложения лечебных мероприятий, оптимальное время лечения и реабилитационных мероприятий, медикаментозную профилактику рецидива.</p></abstract><trans-abstract xml:lang="en"><p>Degenerative diseases that involve excessive formation of fibrous tissue are complex and common problems. These diseases cause pronounced and often irreversible changes, resulting in the dysfunction of the affected organ. Osteoarthritis, osteoarthritis, and arthrofibrosis are pathological conditions characterized by chronic inflammation and excessive proliferation of connective tissue. The elbow joint, being the most mobile and anatomically stable joint in humans, is often affected by arthrofibrosis, resulting in significant functional impairment and reduced quality of life for patients. This problem has significant social relevance. Understanding the mechanisms that lead to arthrofibrosis can help determine the most effective therapeutic interventions, the optimal timing for treatment and rehabilitation, and the use of preventive measures to reduce the risk of relapse.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>артрофиброз локтевого сустава</kwd><kwd>фиброз</kwd><kwd>патогенез фиброза</kwd><kwd>факторы развития артрофиброза</kwd><kwd>профилактика артрофиброза</kwd></kwd-group><kwd-group xml:lang="en"><kwd>arthrofibrosis of the elbow joint</kwd><kwd>fibrosis</kwd><kwd>pathogenesis of fibrosis</kwd><kwd>factors of development of arthrofibrosis</kwd><kwd>prevention of arthrofibrosis</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Adolfsson L. Post-traumatic stiff elbow. EFORT Open Rev. 2018;3(5):210—216. https://doi.org/10.1302/2058-5241.3.170062.</mixed-citation><mixed-citation xml:lang="en">Adolfsson L. Post-traumatic stiff elbow. EFORT Open Rev. 2018;3(5):210—216. https://doi.org/10.1302/2058-5241.3.170062.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Masci G, Cazzato G, Milano G, Ciolli G, Malerba G, Perisano C, Greco T, Osvaldo P, Maccauro G, Liuzza F. The stiff elbow: Current concepts. Orthop Rev (Pavia). 2020. Jun 25;12(Suppl 1):8661. https://doi.org/10.4081/or.2020.8661.</mixed-citation><mixed-citation xml:lang="en">Masci G, Cazzato G, Milano G, Ciolli G, Malerba G, Perisano C, Greco T, Osvaldo P, Maccauro G, Liuzza F. The stiff elbow: Current concepts. Orthop Rev (Pavia). 2020. Jun 25;12(Suppl 1):8661. https://doi.org/10.4081/or.2020.8661.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Nandi S, Maschke S, Evans PJ, Lawton JN. The stiff elbow. Hand. 2009;4(4):368—379. https://doi.org/10.1007/s11552-009-9181-z.</mixed-citation><mixed-citation xml:lang="en">Nandi S, Maschke S, Evans PJ, Lawton JN. The stiff elbow. Hand. 2009;4(4):368—379. https://doi.org/10.1007/s11552-009-9181-z.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Ravalli S, Pulici C, Binetti S, Aglieco A, Vecchio M, Musumeci G. An Overview of the Pathogenesis and Treatment of Elbow Osteoarthritis. J Funct Morphol Kinesiol. 2019. https://doi.org/10.3390/jfmk4020030.</mixed-citation><mixed-citation xml:lang="en">Ravalli S, Pulici C, Binetti S, Aglieco A, Vecchio M, Musumeci G. An Overview of the Pathogenesis and Treatment of Elbow Osteoarthritis. J Funct Morphol Kinesiol. 2019. https://doi.org/10.3390/jfmk4020030.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Mittal R. Posttraumatic stiff elbow. Indian J Orthop. 2017;51(1):4—13. https://doi.org/10.4103/0019-5413.197514.</mixed-citation><mixed-citation xml:lang="en">Mittal R. Posttraumatic stiff elbow. Indian J Orthop. 2017;51(1):4—13. https://doi.org/10.4103/0019-5413.197514.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Zhang D, Nazarian A, Rodriguez EK. Post-traumatic elbow stiffness: Pathogenesis and current treatments. Shoulder Elb. 2020;12(1):38—45. https://doi.org/10.1177/1758573218793903.</mixed-citation><mixed-citation xml:lang="en">Zhang D, Nazarian A, Rodriguez EK. Post-traumatic elbow stiffness: Pathogenesis and current treatments. Shoulder Elb. 2020;12(1):38—45. https://doi.org/10.1177/1758573218793903.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Ратьев А. П., Егиазарян К. А., Жаворонков Е. А., Мельников В. С. Лечение остеоартроза локтевого сустава. Вопросы реконструктивной и пластической хирургии. 2014;2:50—60.</mixed-citation><mixed-citation xml:lang="en">Rat'ev AP, Egiazarjan KA, Zhavoronkov EA, Mel'nikov VS. The treatment of osteoarthritis of the elbow joint. Voprosy rekonstruktivnoj i plasticheskoj hirurgii. 2014;2:50—60 (in Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Evans PJ, Nandi S, Maschke S, Hoyen HA, Lawton JN. Prevention and Treatment of Elbow Stiffness. J Hand Surg Am. 2009;34(4):769—778. https://doi.org/10.1016/j.jhsa.2009.02.020.</mixed-citation><mixed-citation xml:lang="en">Evans PJ, Nandi S, Maschke S, Hoyen HA, Lawton JN. Prevention and Treatment of Elbow Stiffness. J Hand Surg Am. 2009;34(4):769—778. https://doi.org/10.1016/j.jhsa.2009.02.020.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Gracitelli MEC, Guglielmetti CLB, Botelho CAS, Malavolta EA, Assuncao JH, Neto AAF. Surgical treatment of post-traumatic elbow stiffness by wide posterior approach. Rev Bras Ortop. 2020;55(5):570—578. https://doi.org/10.1055/s-0039-1700827.</mixed-citation><mixed-citation xml:lang="en">Gracitelli MEC, Guglielmetti CLB, Botelho CAS, Malavolta EA, Assuncao JH, Neto AAF. Surgical treatment of post-traumatic elbow stiffness by wide posterior approach. Rev Bras Ortop. 2020;55(5):570—578. https://doi.org/10.1055/s-0039-1700827.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Sardelli M, Tashjian RZ, MacWilliams BA. Functional elbow range of motion for contemporary tasks. J Bone Jt Surg — Ser A. 2011;93(5):471—477. https://doi.org/10.2106/JBJS.I.01633.</mixed-citation><mixed-citation xml:lang="en">Sardelli M, Tashjian RZ, MacWilliams BA. Functional elbow range of motion for contemporary tasks. J Bone Jt Surg — Ser A. 2011;93(5):471—477. https://doi.org/10.2106/JBJS.I.01633.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Klein SL, Flanagan KL. Sex differences in immune responses. Nat Rev Immunol. 2016;16(10):626—638. https://doi.org/10.1038/NRI.2016.90.</mixed-citation><mixed-citation xml:lang="en">Klein SL, Flanagan KL. Sex differences in immune responses. Nat Rev Immunol. 2016;16(10):626—638. https://doi.org/10.1038/NRI.2016.90.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Schrumpf MA, Lyman S, Do H, et al. Incidence of postoperative elbow contracture release in New York State. J Hand Surg Am. 2013;38(9). https://doi.org/10.1016/j.jhsa.2013.05.005.</mixed-citation><mixed-citation xml:lang="en">Schrumpf MA, Lyman S, Do H, et al. Incidence of postoperative elbow contracture release in New York State. J Hand Surg Am. 2013;38(9). https://doi.org/10.1016/j.jhsa.2013.05.005.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Sanders TL, Kremers HM, Bryan AJ, Kremers WK, Stuart MJ, Krych AJ. Procedural Intervention for Arthrofibrosis after ACL reconstruction: Trends over Two Decades. Knee Surg Sports Traumatol Arthrosc. 2017;25(2):532. https://doi.org/10.1007/S00167-015-3799-X.</mixed-citation><mixed-citation xml:lang="en">Sanders TL, Kremers HM, Bryan AJ, Kremers WK, Stuart MJ, Krych AJ. Procedural Intervention for Arthrofibrosis after ACL reconstruction: Trends over Two Decades. Knee Surg Sports Traumatol Arthrosc. 2017;25(2):532. https://doi.org/10.1007/S00167-015-3799-X.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Usher KM, Zhu S, Mavropalias G, Carrino JA, Zhao J, Xu J. Pathological mechanisms and therapeutic outlooks for arthrofibrosis. Bone Res. 2019;7(1). https://doi.org/10.1038/s41413-019-0047-x.</mixed-citation><mixed-citation xml:lang="en">Usher KM, Zhu S, Mavropalias G, Carrino JA, Zhao J, Xu J. Pathological mechanisms and therapeutic out-looks for arthrofibrosis. Bone Res. 2019;7(1). https://doi.org/10.1038/s41413-019-0047-x.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Wessel LE, Gu A, Richardson SS, Fufa DT, Osei DA. Elbow contracture following operative fixation of fractures about the elbow. JSES Open Access. 2019;3(4):261—265. https://doi.org/10.1016/j.jses.2019.09.004.</mixed-citation><mixed-citation xml:lang="en">Wessel LE, Gu A, Richardson SS, Fufa DT, Osei DA. Elbow contracture following operative fixation of fractures about the elbow. JSES Open Access. 2019;3(4):261—265. https://doi.org/10.1016/j.jses.2019.09.004.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Fan D, Wang W, Hildebrand KA, Fan CY. Open arthrolysis for elbow stiffness increases carrying angle but has no impact on functional recovery. BMC Musculoskelet Disord. 2016;17(1). https://doi.org/10.1186/s12891-016-1205-6.</mixed-citation><mixed-citation xml:lang="en">Fan D, Wang W, Hildebrand KA, Fan CY. Open arthrolysis for elbow stiffness increases carrying angle but has no impact on functional recovery. BMC Musculoskelet Disord. 2016;17(1). https://doi.org/10.1186/s12891-016-1205-6.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Rai S, Zhang Q, Tamang N, Jin S, Wang H, Meng C. Arthroscopic arthrolysis of posttraumatic and non-traumatic elbow stiffness offers comparable clinical outcomes. BMC Musculoskelet Disord. 2019. Jun 15;20(1):285. https://doi.org/10.1186/s12891-019-2666-1.</mixed-citation><mixed-citation xml:lang="en">Rai S, Zhang Q, Tamang N, Jin S, Wang H, Meng C. Arthroscopic arthrolysis of posttraumatic and non-traumatic elbow stiffness offers comparable clinical outcomes. BMC Musculoskelet Disord. 2019. Jun 15;20(1):285. https://doi.org/10.1186/s12891-019-2666-1.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Baranowski A, Schlemmer L, Forster K, Slotina E, Mickan T, Truffel S, Klein A, Mattyasovszky SG, Hofmann A, Ritz U, Rommens PM. Effects of losartan and atorvastatin on the development of early posttraumatic joint stiffness in a rat model. Drug Des Devel Ther. 2019. Jul 30;13:2603—2618. https://doi.org/10.2147/DDDT.S204135.</mixed-citation><mixed-citation xml:lang="en">Baranowski A, Schlemmer L, Forster K, Slotina E, Mickan T, Truffel S, Klein A, Mattyasovszky SG, Hofmann A, Ritz U, Rommens PM. Effects of losartan and atorvastatin on the development of early posttraumatic joint stiffness in a rat model. Drug Des Devel Ther. 2019. Jul 30;13:2603—2618. https://doi.org/10.2147/DDDT.S204135.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Li X, Zhu L, Wang B, Yuan M, Zhu R. Drugs and targets in fibrosis. Front Pharmacol. 2017;8(NOV):855. https://doi.org/10.3389/fphar.2017.00855.</mixed-citation><mixed-citation xml:lang="en">Li X, Zhu L, Wang B, Yuan M, Zhu R. Drugs and targets in fibrosis. Front Pharmacol. 2017;8(NOV):855. https://doi.org/10.3389/fphar.2017.00855.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Salib CG, Reina N, Trousdale WH, Limberg AK, Tibbo ME, Jay AG, Robin JX, Turner TW, Jones CR, Paradise CR, Lewallen EA, Bolon B, Carter JM, Berry DJ, Morrey ME, Sanchez-Sotelo J, van Wijnen AJ, Abdel MP. Inhibition of COX-2 Pathway as a Potential Prophylaxis Against Arthrofibrogenesis in a Rabbit Model of Joint Contracture. J Orthop Res. 2019;37(12):2609—2620. https://doi.org/10.1002/jor.24441.</mixed-citation><mixed-citation xml:lang="en">Salib CG, Reina N, Trousdale WH, Limberg AK, Tibbo ME, Jay AG, Robin JX, Turner TW, Jones CR, Paradise CR, Lewallen EA, Bolon B, Carter JM, Berry DJ, Morrey ME, Sanchez-Sotelo J, van Wijnen AJ, Abdel MP. Inhibition of COX-2 Pathway as a Potential Prophylaxis Against Arthrofibrogenesis in a Rabbit Model of Joint Contracture. J Orthop Res. 2019;37(12):2609—2620. https://doi.org/10.1002/jor.24441.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Wenzke KE, Cantemir-Stone C, Zhang J, Marsh CB, Huang K. Identifying common genes and networks in multi-organ fibrosis. AMIA Jt Summits Transl Sci Proc. 2012;2012:106—115.</mixed-citation><mixed-citation xml:lang="en">Wenzke KE, Cantemir-Stone C, Zhang J, Marsh CB, Huang K. Identifying common genes and networks in multi-organ fibrosis. AMIA Jt Summits Transl Sci Proc. 2012;2012:106—115.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Kendall RT, Feghali-Bostwick CA. Fibroblasts in fibrosis: novel roles and mediators. Front Pharmacol. 2014. May 27;5:123. https://doi.org/10.3389/FPHAR.2014.00123.</mixed-citation><mixed-citation xml:lang="en">Kendall RT, Feghali-Bostwick CA. Fibroblasts in fibrosis: novel roles and mediators. Front Pharmacol. 2014. May 27;5:123. https://doi.org/10.3389/FPHAR.2014.00123.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Li B, Wang JH-C. Fibroblasts and Myofibroblasts in Wound Healing: Force Generation and Measurement. J Tissue Viability. 2011;20(4):108. https://doi.org/10.1016/J.JTV.2009.11.004.</mixed-citation><mixed-citation xml:lang="en">Li B, Wang JH-C. Fibroblasts and Myofibroblasts in Wound Healing: Force Generation and Measurement. J Tissue Viability. 2011;20(4):108. https://doi.org/10.1016/J.JTV.2009.11.004.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Morrey ME, Sanchez-Sotelo J, Lewallen EA, An KN, Grill DE, Steinmann SP, Yao JJ, Salib CG, Trousdale WH, Reina N, Kremers HM, Lewallen DG, van Wijnen AJ, Abdel MP. Intra-articular injection of a substance P inhibitor affects gene expression in a joint contracture model. J Cell Biochem. 2018. Feb 119(2):1326-1336. https://doi.org/10.1002/JCB.26256.</mixed-citation><mixed-citation xml:lang="en">Morrey ME, Sanchez-Sotelo J, Lewallen EA, An KN, Grill DE, Steinmann SP, Yao JJ, Salib CG, Trousdale WH, Reina N, Kremers HM, Lewallen DG, van Wijnen AJ, Abdel MP. Intra-articular injection of a substance P inhibitor affects gene expression in a joint contracture model. J Cell Biochem. 2018. Feb 119(2):1326—1336. https://doi.org/10.1002/JCB.26256.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Меденец О. Д. Гистология, цитология, эмбриология. Витебск: ВГМУ; 2014, 439 с.</mixed-citation><mixed-citation xml:lang="en">Medenec OD. Histology, cytology, embryology. M.: Vitebsk: VGMU; 2014, 439 p. (in Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Остроушко А. П., Андреев А. А., Лаптиёва А. Ю., Глухов А. А. Коллаген и его применение при лечении ран. Вестник экспериментальной и клинической хирургии. 2021;14(1):85—90. https://doi.org/10.18499/2070-478X-2021-14-1-85-90.</mixed-citation><mixed-citation xml:lang="en">Ostroushko AP, Andreev AA, Laptiyova AY, Gluhov AA. Collagen and Use Its in the Treatment of Wounds. Vestnik eksperimental'noj i klinicheskoj hirurgii. 2021;14(1):85—90 (in Russ.). https://doi.org/10.18499/2070-478X-2021-14-1-85-90.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">McKleroy W, Lee T-H, Atabai K. Always cleave up your mess: targeting collagen degradation to treat tissue fibrosis. Am J Physiol — Lung Cell Mol Physiol. 2013;304(11):L709. https://doi.org/10.1152/AJPLUNG.00418.2012.</mixed-citation><mixed-citation xml:lang="en">McKleroy W, Lee T-H, Atabai K. Always cleave up your mess: targeting collagen degradation to treat tissue fibrosis. Am J Physiol — Lung Cell Mol Physiol. 2013;304(11):L709. https://doi.org/10.1152/AJPLUNG.00418.2012.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Rockey DC, Bell PD, Hill JA. Fibrosis — A Common Pathway to Organ Injury and Failure. N Engl J Med. 2015;372(12):1138—1149. https://doi.org/10.1056/nejmra1300575.</mixed-citation><mixed-citation xml:lang="en">Rockey DC, Bell PD, Hill JA. Fibrosis — A Common Pathway to Organ Injury and Failure. N Engl J Med. 2015;372(12):1138—1149. https://doi.org/10.1056/nejmra1300575.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Wynn TA, Barron L. Macrophages: Master Regulators of Inflammation and Fibrosis. Semin Liver Dis. 2010;30(3):245. https://doi.org/10.1055/S-0030-1255354.</mixed-citation><mixed-citation xml:lang="en">Wynn TA, Barron L. Macrophages: Master Regulators of Inflammation and Fibrosis. Semin Liver Dis. 2010;30(3):245. https://doi.org/10.1055/S-0030-1255354.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Хаитов Р. М. Иммунология: структура и функции иммунной системы. М.: ГЭОТАР-Медиа; 2014, 68 с.</mixed-citation><mixed-citation xml:lang="en">Haitov RM. Immunology: structure and functions of the immune system. M.: GEOTAR-Media; 2014, 68 p. (in Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Wynn TA. Fibrotic disease and the TH1/TH2 paradigm. Nat Rev Immunol. 2004;4(8):583. https://doi.org/10.1038/NRI1412.</mixed-citation><mixed-citation xml:lang="en">Wynn TA. Fibrotic disease and the TH1/TH2 paradigm. Nat Rev Immunol. 2004;4(8):583. https://doi.org/10.1038/NRI1412.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Flanders KC. Smad3 as a mediator of the fibrotic response. Int J Exp Pathol. 2004;85(2):47. https://doi.org/10.1111/J.0959-9673.2004.00377.X.</mixed-citation><mixed-citation xml:lang="en">Flanders KC. Smad3 as a mediator of the fibrotic response. Int J Exp Pathol. 2004;85(2):47. https://doi.org/10.1111/J.0959-9673.2004.00377.X.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Frangogiannis NG. Transforming growth factor-в in tissue fibrosis. J Exp Med. 2020;217(3). https://doi.org/10.1084/JEM.20190103.</mixed-citation><mixed-citation xml:lang="en">Frangogiannis NG. Transforming growth factor-в in tissue fibrosis. J Exp Med. 2020;217(3). https://doi.org/10.1084/JEM.20190103.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Gilbert RWD, Vickaryous MK, Viloria-Petit AM. Signalling by Transforming Growth Factor Beta Isoforms in Wound Healing and Tissue Regeneration. J Dev Biol. 2016;4(2):21. https://doi.org/10.3390/JDB4020021.</mixed-citation><mixed-citation xml:lang="en">Gilbert RWD, Vickaryous MK, Viloria-Petit AM. Signalling by Transforming Growth Factor Beta Isoforms in Wound Healing and Tissue Regeneration. J Dev Biol. 2016;4(2):21. https://doi.org/10.3390/JDB4020021.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Bracey NA, Gershkovich B, Chun J, Vilaysane A, Meijndert HC, Wright JR Jr, Fedak PW, Beck PL, Muruve DA, Duff HJ. Mitochondrial NLRP3 protein induces reactive oxygen species to promote Smad protein signaling and fibrosis independent from the inflammasome. J Biol Chem. 2014. Jul 11;289(28):19571—19584. https://doi.org/10.1074/JBC.M114.550624.</mixed-citation><mixed-citation xml:lang="en">Bracey NA, Gershkovich B, Chun J, Vilaysane A, Meijndert HC, Wright JR Jr, Fedak PW, Beck PL, Muruve DA, Duff HJ. Mitochondrial NLRP3 protein induces reactive oxygen species to promote Smad protein signaling and fibrosis independent from the inflammasome. J Biol Chem. 2014. Jul 11;289(28):19571—19584. https://doi.org/10.1074/JBC.M114.550624.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Cordero MD, Alcocer-Gómez E, Culic O, Carrión AM, de Miguel M, Díaz-Parrado E, Pérez-Villegas EM, BullónP, Battino M, Sánchez-Alcazar JA. NLRP3 inflammasome is activated in fibromyalgia: the effect of coenzyme Q10. Antioxid Redox Signal. 2014. Mar 10;20(8):1169—1180. https://doi.org/10.1089/ARS.2013.5198.</mixed-citation><mixed-citation xml:lang="en">Cordero MD, Alcocer-Gomez E, Culic O, Carrion AM, de Miguel M, D^az-Parrado E, Perez-Villegas EM, Bullon P, Battino M, Sanchez-Alcazar JA. NLRP3 inflammasome is activated in fibromyalgia: the effect of coenzyme Q10. Antioxid Redox Signal. 2014. Mar 10;20(8):1169—1180. https://doi.org/10.1089/ARS.2013.5198.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Liu RM, Pravia KAG. Oxidative stress and glutathione in TGF-p-mediated fibrogenesis. Free Radic Biol Med. 2010;48(1):1. https://doi.org/10.1016/J.FREERADBIOMED.2009.09.026.</mixed-citation><mixed-citation xml:lang="en">Liu RM, Pravia KAG. Oxidative stress and glutathione in TGF-p-mediated fibrogenesis. Free Radic Biol Med. 2010;48(1):1. https://doi.org/10.1016/J.FREERADBIOMED.2009.09.026.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Gasse P, Mary C, Guenon I, Noulin N, Charron S, Schnyder-Candrian S, Schnyder B, Akira S, Quesniaux VF, Lagente V, Ryffel B, Couillin I. IL-1R1/MyD88 signaling and the inflammasome are essential in pulmonary inflammation and fibrosis in mice. J Clin Invest. 2007. Dec 117(12):3786—3799. https://doi.org/10.1172/JCI32285.</mixed-citation><mixed-citation xml:lang="en">Gasse P, Mary C, Guenon I, Noulin N, Charron S, Schnyder-Candrian S, Schnyder B, Akira S, Quesniaux VF, Lagente V, Ryffel B, Couillin I. IL-1R1/MyD88 signaling and the inflammasome are essential in pulmonary inflammation and fibrosis in mice. J Clin Invest. 2007. Dec 117(12):3786—3799. https://doi.org/10.1172/JCI32285.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Seki E, Schwabe RF. Hepatic Inflammation and Fibrosis: Functional Links and Key Pathways. Hepatology. 2015;61(3):1066. https://doi.org/10.1002/HEP.27332.</mixed-citation><mixed-citation xml:lang="en">Seki E, Schwabe RF. Hepatic Inflammation and Fibrosis: Functional Links and Key Pathways. Hepatology. 2015;61(3):1066. https://doi.org/10.1002/HEP.27332.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Fielding CA, Jones GW, McLoughlin RM, McLeod L, Hammond VJ, Uceda J, Williams AS, Lambie M, Foster TL, Liao CT, Rice CM, Greenhill CJ, Colmont CS, Hams E, Coles B, Kift-Morgan A, Newton Z, Craig KJ, Williams JD, Williams GT, Davies SJ, Humphreys IR, O'Donnell VB, Taylor PR, Jenkins BJ, Topley N, Jones SA. Interleukin-6 signaling drives fibrosis in unresolved inflammation. Immunity. 2014. Jan 16;40(1):40—50. https://doi.org/10.1016/J.IMMUNI.2013.10.022.</mixed-citation><mixed-citation xml:lang="en">Fielding CA, Jones GW, McLoughlin RM, McLeod L, Hammond VJ, Uceda J, Williams AS, Lambie M, Foster TL, Liao CT, Rice CM, Greenhill CJ, Colmont CS, Hams E, Coles B, Kift-Morgan A, Newton Z, Craig KJ, Williams JD, Williams GT, Davies SJ, Humphreys IR, O'Donnell VB, Taylor PR, Jenkins BJ, Topley N, Jones SA. Interleukin-6 signaling drives fibrosis in unresolved inflammation. Immunity. 2014. Jan 16;40(1):40—50. https://doi.org/10.1016/J.IMMUNI.2013.10.022.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Barnes TC, Anderson ME, Moots RJ. The Many Faces of Interleukin-6: The Role of IL-6 in Inflammation, Vasculopathy, and Fibrosis in Systemic Sclerosis. Int J Rheumatol. 2011;2011:721608. https://doi.org/10.1155/2011/721608.</mixed-citation><mixed-citation xml:lang="en">Barnes TC, Anderson ME, Moots RJ. The Many Faces of Interleukin-6: The Role of IL-6 in Inflammation, Vasculopathy, and Fibrosis in Systemic Sclerosis. Int J Rheumatol. 2011;2011:721608. https://doi.org/10.1155/2011/721608.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Luckett-Chastain LR, Cottrell ML, Kawar BM, Ihnat MA, Gallucci RM. Interleukin (IL)-6 modulates transforming growth factor-в receptor I and II (TGF-eRI and II) function in epidermal keratinocytes. Exp Dermatol. 2017;26(8):697. https://doi.org/10.1111/EXD.13260.</mixed-citation><mixed-citation xml:lang="en">Luckett-Chastain LR, Cottrell ML, Kawar BM, Ihnat MA, Gallucci RM. Interleukin (IL)-6 modulates transforming growth factor-в receptor I and II (TGF-eRI and II) function in epidermal keratinocytes. Exp Dermatol. 2017;26(8):697. https://doi.org/10.1111/EXD.13260.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Ng B, Cook SA, Schafer S. Interleukin-11 signaling underlies fibrosis, parenchymal dysfunction, and chronic inflammation of the airway. Exp Mol Med. 2020;52(12):1871. https://doi.org/10.1038/S12276-020-00531-5.</mixed-citation><mixed-citation xml:lang="en">Ng B, Cook SA, Schafer S. Interleukin-11 signaling underlies fibrosis, parenchymal dysfunction, and chronic inflammation of the airway. Exp Mol Med. 2020;52(12):1871. https://doi.org/10.1038/S12276-020-00531-5.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA. Interleukins (from IL-1 to IL-38), interferons, transforming growth factor в, and TNF-a: Receptors, functions, and roles in diseases. J Allergy Clin Immunol. 2016. Oct 138(4):984—1010. https://doi.org/10.1016/j.jaci.2016.06.033.</mixed-citation><mixed-citation xml:lang="en">Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA. Interleukins (from IL-1 to IL-38), interferons, transforming growth factor в, and TNF-a: Receptors, functions, and roles in diseases. J Allergy Clin Immunol. 2016. Oct 138(4):984—1010. https://doi.org/10.1016/j.jaci.2016.06.033.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Sullivan DE, Ferris M, Pociask D, Brody AR. Tumor necrosis factor-alpha induces transforming growth factor-beta1 expression in lung fibroblasts through the extracellular signal-regulated kinase pathway. Am J Respir Cell Mol Biol. 2005. Apr 32(4):342—349. https://doi.org/10.1165/rcmb.2004-0288OC.</mixed-citation><mixed-citation xml:lang="en">Sullivan DE, Ferris M, Pociask D, Brody AR. Tumor necrosis factor-alpha induces transforming growth factor-beta1 expression in lung fibroblasts through the extracellular signal-regulated kinase pathway. Am J Respir Cell Mol Biol. 2005. Apr 32(4):342—349. https://doi.org/10.1165/rcmb.2004-0288OC.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Dinarello CA. Anti-inflammatory Agents: Present and Future. Cell. 2010;140(6):935—950. https://doi.org/10.1016/j.cell.2010.02.043.</mixed-citation><mixed-citation xml:lang="en">Dinarello CA. Anti-inflammatory Agents: Present and Future. Cell. 2010;140(6):935—950. https://doi.org/10.1016/j.cell.2010.02.043.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Oikonomou N, Harokopos V, Zalevsky J, Valavanis C, Kotanidou A, Szymkowski DE, Kollias G, Aidinis V. Soluble TNF mediates the transition from pulmonary inflammation to fibrosis. PLoS One. 2006. Dec 27;1(1):e108. https://doi.org/10.1371/journal.pone.0000108.</mixed-citation><mixed-citation xml:lang="en">Oikonomou N, Harokopos V, Zalevsky J, Valavanis C, Kotanidou A, Szymkowski DE, Kollias G, Aidinis V. Soluble TNF mediates the transition from pulmonary inflammation to fibrosis. PLoS One. 2006. Dec 27;1(1):e108. https://doi.org/10.1371/journal.pone.0000108.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Snelling SJ, Bas S, Puskas GJ, Dakin SG, Suva D, Finckh A, Gabay C, Hoffmeyer P, Carr AJ, Lubbeke A. Presence of IL-17 in synovial fluid identifies a potential inflammatory osteoarthritic phenotype. PLoS One. 2017. Apr 11;12(4):e0175109. https://doi.org/10.1371/JOURNAL.PONE.0175109.</mixed-citation><mixed-citation xml:lang="en">Snelling SJ, Bas S, Puskas GJ, Dakin SG, Suva D, Finckh A, Gabay C, Hoffmeyer P, Carr AJ, Lubbeke A. Presence of IL-17 in synovial fluid identifies a potential inflammatory osteoarthritic phenotype. PLoS One. 2017. Apr 11;12(4):e0175109. https://doi.org/10.1371/JOURNAL.PONE.0175109.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Luo Y, Xie X, Luo D, Wang Y, Gao Y. The role of halofuginone in fibrosis: more to be explored? J Leukoc Biol. 2017;102(6):1333—1345. https://doi.org/10.1189/JLB.3RU0417-148RR.</mixed-citation><mixed-citation xml:lang="en">Luo Y, Xie X, Luo D, Wang Y, Gao Y. The role of halofuginone in fibrosis: more to be explored? J Leukoc Biol. 2017;102(6):1333—1345. https://doi.org/10.1189/JLB.3RU0417-148RR.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Гариб Ф. Ю., Ризопулу А. П. Инфламмасомы и воспаление. Российский иммунологический журнал. 2017;4(20):620—626.</mixed-citation><mixed-citation xml:lang="en">Garib FY, Rizopulu AP. Inflammasomes and inflammation. Rossijskij immunologicheskij zhurnal. 2017;4(20):620—626 (in Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Dorrington MG, Fraser IDC. NF-KB Signaling in Macrophages: Dynamics, Crosstalk, and Signal Integration. Front Immunol. 2019;10(APR):705. https://doi.org/10.3389/FIMMU.2019.00705.</mixed-citation><mixed-citation xml:lang="en">Dorrington MG, Fraser IDC. NF-KB Signaling in Macrophages: Dynamics, Crosstalk, and Signal Integration. Front Immunol. 2019;10(APR):705. https://doi.org/10.3389/FIMMU.2019.00705.</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Ouyang X, Ghani A, Mehal WZ. Inflammasome biology in fibrogenesis. Biochim Biophys Acta. 2013;1832(7):979—988. https://doi.org/10.1016/J.BBADIS.2013.03.020.</mixed-citation><mixed-citation xml:lang="en">Ouyang X, Ghani A, Mehal WZ. Inflammasome biology in fibrogenesis. Biochim Biophys Acta. 2013;1832(7):979—988. https://doi.org/10.1016/J.BBADIS.2013.03.020.</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Zhang WJ, Chen SJ, Zhou SC, Wu SZ, Wang H. Inflammasomes and Fibrosis. Front Immunol. 2021. Jun 11;12:643149. https://doi.org/10.3389/FIMMU.2021.643149.</mixed-citation><mixed-citation xml:lang="en">Zhang WJ, Chen SJ, Zhou SC, Wu SZ, Wang H. Inflammasomes and Fibrosis. Front Immunol. 2021. Jun 11;12:643149. https://doi.org/10.3389/FIMMU.2021.643149.</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Puente A, Fortea JI, Cabezas J, Arias Loste MT, Iruzubieta P, Llerena S, Huelin P, Fabrega E, Crespo J. LOXL2-A New Target in Antifibrogenic Therapy? Int J Mol Sci. 2019. Apr 2;20(7):1634. https://doi.org/10.3390/IJMS20071634.</mixed-citation><mixed-citation xml:lang="en">Puente A, Fortea JI, Cabezas J, Arias Loste MT, Iruzubieta P, Llerena S, Huelin P, Fabrega E, Crespo J. LOXL2-A New Target in Antifibrogenic Therapy? Int J Mol Sci. 2019. Apr 2;20(7):1634. https://doi.org/10.3390/IJMS20071634.</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">Shen J, Li S, Chen D. TGF-p signaling and the development of osteoarthritis. Bone Res. 2014;2:14002. https://doi.org/10.1038/BONERES.2014.2.</mixed-citation><mixed-citation xml:lang="en">Shen J, Li S, Chen D. TGF-p signaling and the development of osteoarthritis. Bone Res. 2014;2:14002. https://doi.org/10.1038/BONERES.2014.2.</mixed-citation></citation-alternatives></ref><ref id="cit56"><label>56</label><citation-alternatives><mixed-citation xml:lang="ru">Bufalino C, Hepgul N, Aguglia E, Pariante CM. The role of immune genes in the association between depression and inflammation: a review of recent clinical studies. Brain Behav Immun. 2013;31:31—47. https://doi.org/10.1016/J.BBI.2012.04.009.</mixed-citation><mixed-citation xml:lang="en">Bufalino C, Hepgul N, Aguglia E, Pariante CM. The role of immune genes in the association between depression and inflammation: a review of recent clinical studies. Brain Behav Immun. 2013;31:31—47. https://doi.org/10.1016/J.BBI.2012.04.009.</mixed-citation></citation-alternatives></ref><ref id="cit57"><label>57</label><citation-alternatives><mixed-citation xml:lang="ru">Huang YP, Fann CY, Chiu YH, Yen MF, Chen LS, Chen HH, Pan SL. Association of diabetes mellitus with the risk of developing adhesive capsulitis of the shoulder: a longitudinal population-based followup study. Arthritis Care Res (Hoboken). 2013. Jul 65(7):1197—1202. https://doi.org/10.1002/ACR.21938.</mixed-citation><mixed-citation xml:lang="en">Huang YP, Fann CY, Chiu YH, Yen MF, Chen LS, Chen HH, Pan SL. Association of diabetes mellitus with the risk of developing adhesive capsulitis of the shoulder: a longitudinal population-based followup study. Arthritis Care Res (Hoboken). 2013. Jul 65(7):1197—1202. https://doi.org/10.1002/ACR.21938.</mixed-citation></citation-alternatives></ref><ref id="cit58"><label>58</label><citation-alternatives><mixed-citation xml:lang="ru">Sun C, Zhou X, Yao C, Poonit K, Fan C, Yan H. The timing of open surgical release of post-traumatic elbow stiffness: A systematic review. Med (United States). 2017;96(49). https://doi.org/10.1097/MD.0000000000009121.</mixed-citation><mixed-citation xml:lang="en">Sun C, Zhou X, Yao C, Poonit K, Fan C, Yan H. The timing of open surgical release of post-traumatic elbow stiffness: A systematic review. Med (United States). 2017;96(49). https://doi.org/10.1097/MD.0000000000009121.</mixed-citation></citation-alternatives></ref><ref id="cit59"><label>59</label><citation-alternatives><mixed-citation xml:lang="ru">Garcia CK. Insights from human genetic studies of lung and organ fibrosis. J Clin Invest. 2018. Jan 2;128(1):36—44. https://doi.org/10.1172/JCI93556.</mixed-citation><mixed-citation xml:lang="en">Garcia CK. Insights from human genetic studies of lung and organ fibrosis. J Clin Invest. 2018. Jan 2;128(1):36—44. https://doi.org/10.1172/JCI93556.</mixed-citation></citation-alternatives></ref><ref id="cit60"><label>60</label><citation-alternatives><mixed-citation xml:lang="ru">Maurya VK, Jha RK, Kumar V, Joshi A, Chadchan S, Mohan JJ, Laloraya M. Transforming growth factor-beta 1 (TGF-B1) liberation from its latent complex during embryo implantation and its regulation by estradiol in mouse. Biol Reprod. 2013. Oct 10;89(4):84. https://doi.org/10.1095/BIOLREPROD.112.106542.</mixed-citation><mixed-citation xml:lang="en">Maurya VK, Jha RK, Kumar V, Joshi A, Chadchan S, Mohan JJ, Laloraya M. Transforming growth factor-beta 1 (TGF-B1) liberation from its latent complex during embryo implantation and its regulation by estradiol in mouse. Biol Reprod. 2013. Oct 10;89(4):84. https://doi.org/10.1095/BIOLREPROD.112.106542.</mixed-citation></citation-alternatives></ref><ref id="cit61"><label>61</label><citation-alternatives><mixed-citation xml:lang="ru">Roved J, Westerdahl H, Hasselquist D. Sex differences in immune responses: Hormonal effects, antagonistic selection, and evolutionary consequences. Horm Behav. 2017;88:95—105. https://doi.org/10.1016/J.YH-BEH.2016.11.017.</mixed-citation><mixed-citation xml:lang="en">Roved J, Westerdahl H, Hasselquist D. Sex differences in immune responses: Hormonal effects, antagonistic selection, and evolutionary consequences. Horm Behav. 2017;88:95—105. https://doi.org/10.1016/J.YH-BEH.2016.11.017.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
