spracticeХирургическая практикаSurgical practice (Russia)2223-2427АНО "Консорциум "Медицинская техника"10.38181/2223-2427-2022-3-42-48spractice-331Research ArticleСтатьиСОВРЕМЕННОЕ СОСТОЯНИЕ ПРОБЛЕМЫ В ТРАНСПЛАНТАЦИИ ОРГАНОВ У ВИЧ-ИНФИЦИРОВАННЫХ ПАЦИЕНТОВ ЗА РУБЕЖОМ И В РОССИЙСКОЙ ФЕДЕРАЦИИTHE CURRENT STATE OF THE PROBLEM IN ORGAN TRANSPLANTATION IN HIV-INFECTED PATIENTS ABROAD AND IN THE RUSSIAN FEDERATIONhttps://orcid.org/0000-0001-5330-070XМалашенкоА. А.MalashenkoA. A.

Малашенко Андрей Александрович – к.м.н., начальник хирургического отделения филиала «Больница № 1»

пр. Ленина д. 123, кв. 101. г. Кемерово, 650056

Тел.: 8905 069 00 32

Andrey А. Malashenko – PhD, Head of the surgical department of the branch «Hospital No. 1»

123 Lenin Ave., 101 sq., Kemerovo, 650056

Phone: 8905 069 00 32

malashenko_aa@mail.ruhttps://orcid.org/0000-0001-9046-6637ЦыплинаЕ. Ю.TsyplinaE. Yu.

Цыплина Екатерина Юрьевна – студент лечебного факультета 5 курса

г. Томск

Ekaterina Y. Tsyplina – 5th year student of the Medical Faculty

Tomsk

katyts9917@gmail.comhttps://orcid.org/0000-0001-7617-6422КрасновА. О.KrasnovA. O.

Краснов Аркадий Олегович – к.м.н., врач-хирург хирургического отделения № 2

Arkadiy O. Krasnov – PhD

aokrasnov@mail.ruhttps://orcid.org/0000-0003-1178-5205АнищенкоВ. В.AnishchenkoV. V.

Анищенко Владимир Владимирович – д.м.н., профессор, научный руководитель клиники хирургии АО медицинского центра Авицена, группы компаний «Мать и Дитя»; заведующий кафедрой хирургии факультета повышения квалификации и профессиональной переподготовки врачей Федерального государственного бюджетного образовательного учреждения высшего образования «Новосибирский государственный медицинский университет»

г. Новосибирск

Vladimir V. Anishchenko – Dr. Sci., Professor, Scientific Director of the Surgery clinic of Avicena Medical Center JSC, Mother and Child Group of Companies; Head of the Department of Surgery of the Faculty of Advanced Training and Professional Retraining of Doctors of the Federal State Budgetary Educational Institution of Higher Education «Novosibirsk State Medical University»

Novosibirsk

avv1110@yandex.ruhttps://orcid.org/0000-0002-5214-7771КрасновО. А.KrasnovO. A.

Краснов Олег Аркадьевич – д.м.н., профессор кафедры общей, факультетской хирургии и урологии Кемеровского государственного медицинского университета, начальник Поликлиники №1, ГАУЗ «Клинический консультативно-диагностический центр им. И. А. Колпинского»

г. Кемерово

Oleg А. Krasnov – Dr. Sci., Professor of the Department of General, Faculty Surgery and Urology of Kemerovo State Medical University; Head of Polyclinic No. 1, I. A. Kolpinsky Clinical Consulting and Diagnostic Center

Kemerovo

xo1@mail.ruФедеральное казенное учреждение Медико-санитарная часть № 42 Федеральной службы исполнения наказаний России, филиал «Больница №1»РоссияFederal state Institution Medical and Sanitary Unit No. 42 of the Federal Penitentiary Service of Russia, branch «Hospital No. 1»Russian FederationФедеральное государственное бюджетное образовательное учреждение высшего образования «Сибирский государственный медицинский университет»РоссияFederal State Budgetary Educational Institution of Higher Education «Siberian State Medical University»Russian FederationГосударственное автономное учреждение здравоохранения «Кузбасская клиническая больница скорой помощи им. М. А. Подгорбунского»РоссияState Autonomous Health Institution "Kuzbass Clinical Emergency Hospital named after M. A. PodgorbunskyRussian FederationФедеральное государственное бюджетное образовательное учреждение высшего образования «Новосибирский государственный медицинский университет», кафедра хирургии факультет повышения квалификации и профессиональной переподготовки врачей; АО медицинский центр Авицена, группа компаний «Мать и Дитя»РоссияFederal State Budgetary Educational Institution of Higher Education «Novosibirsk State Medical University», Department of Surgery, Faculty of Advanced Training and Professional Retraining of Doctors; Avicena Medical Center JSC, Mother and Child Group of companiesRussian FederationФедеральное бюджетное образовательное учреждение высшего образования Кемеровский государственный медицинский университет, кафедра общей, факультетской хирургии и урологии; ГАУЗ «Клинический консультативно-диагностический центр им. И.А. Колпинского», поликлиника № 1РоссияFederal Budgetary Educational Institution of Higher Education Kemerovo State Medical University; Department of General, Faculty Surgery and Urology, I. A. Kolpinsky Clinical Consulting and Diagnostic Center, Polyclinic No. 1Russian Federation202222092022034248Copyright © Малашенко А.А., Цыплина Е.Ю., Краснов А.О., Анищенко В.В., Краснов О.А., 20222022Малашенко А.А., Цыплина Е.Ю., Краснов А.О., Анищенко В.В., Краснов О.А.Malashenko A.A., Tsyplina E.Y., Krasnov A.O., Anishchenko V.V., Krasnov O.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.spractice.ru/jour/article/view/331

Работа основана на ретроспективном анализе данных литературы, освещающих тактические подходы, показания и противопоказания, результаты лечения у больных с ВИЧ-инфекцией, которым проводилась трансплантация органов. Проведен анализ наиболее современных публикаций по трансплантации органов у ВИЧ-инфицированных больных в Российской Федерации и за рубежом. Отмечены критерии, при которых наиболее благоприятно проходит трансплантация у ВИЧ-инфицированного пациента. Описаны случаи трансплантации с последующими результатами: донор (ВИЧ-) – реципиент (ВИЧ+), донор (ВИЧ+) – РЕЦИПИЕНТ (ВИЧ+) и донор (ВИЧ+) – РЕЦИПИЕНТ (ВИЧ-). Главная цель обзора – провести анализ современной зарубежной и отечественной литературы в вопросе тактических подходов трансплантации органов у ВИЧ-инфицированных пациентов. Установлено, что в разных странах имеется различный подход к проведению трансплантации органов у ВИЧ-инфицированных больных.

The work is based on a retrospective analysis of literature data covering tactical approaches, indications and contraindications, treatment results in patients with HIV infection who underwent organ transplantation. The analysis of the most up-to-date publications on organ transplantation in HIV-infected patients in the Russian Federation and abroad has been carried out. The criteria under which the transplantation of an HIV-infected patient is most favorable are noted. Cases of transplantation with subsequent results are described: donor (HIV-) – recipient (HIV+), donor (HIV+) – RECIPIENT (HIV+) and donor (HIV+) – RECIPIENT (HIV-). The main purpose of the review is to analyze modern foreign and domestic literature on the issue of tactical approaches to organ transplantation in HIV-infected patients. It has been established that different countries have different approaches to organ transplantation in HIV-infected patients.

ВИЧ-инфекциятрансплантациядонорреципиентHIV infectiontransplantationdonorrecipientReferencesBoyarsky BJ, Durand CM, Palella FJ, Segev DL Challenges and clinical decision-making in HIV-to-HIV transplantation: insights from the HIV literature. Am J Transplant. 2015;15(8):2023-2030. https://doi.org/10.1111/ajt.13344Boyarsky BJ, Durand CM, Palella FJ, Segev DL Challenges and clinical decision-making in HIV-to-HIV transplantation: insights from the HIV literature. Am J Transplant. 2015;15(8):2023-2030. https://doi.org/10.1111/ajt.13344Pierrotti LC, Litvinov N, Costa SF, de Azevedo LSF, VarejãoStrabelli TM, Campos SV, AtienoOdongo FC, Reusing-Junior JO, Song ATW, Banks MI, Lopes F, Batista MV, Lopes MH, Maluf NZ, Caiaffa-Filho HH, de Oliveira MS, de Sousa Marques HH, Abdala E. A Brazilian university hospital position regarding transplantation criteria for HIV- positive patients according to the current literature. Clinics (Sao Paulo). 2019;74:e941. https://doi.org/10.6061/clinics/2019/e941Pierrotti LC, Litvinov N, Costa SF, de Azevedo LSF, VarejãoStrabelli TM, Campos SV, AtienoOdongo FC, Reusing-Junior JO, Song ATW, Banks MI, Lopes F, Batista MV, Lopes MH, Maluf NZ, Caiaffa-Filho HH, de Oliveira MS, de Sousa Marques HH, Abdala E. A Brazilian university hospital position regarding transplantation criteria for HIV- positive patients according to the current literature. Clinics (Sao Paulo). 2019;74:e941. https://doi.org/10.6061/clinics/2019/e941Muller E, Kahn D, Mendelson M. Renal transplantation between HIV-positive donors and recipients. N Engl J Med. 2010;362(24):2336-2337. https://doi.org/10.1056/NEJMc0900837Muller E, Kahn D, Mendelson M. Renal transplantation between HIV-positive donors and recipients. N Engl J Med. 2010;362(24):2336-2337. https://doi.org/10.1056/NEJMc0900837Durand CM, Zhang W, Brown DM, Yu S, Desai N, Redd AD, Bagnasco SM, Naqvi FF, Seaman S, Doby BL, Ostrander D, Bowring MG, Eby Y, Fernandez RE, Friedman-Moraco R, Turgeon N, Stock P, Chin-Hong P, Mehta S, Stosor V, Small CB, Gupta G, Mehta SA, Wolfe CR, Husson J, Gilbert A, Cooper M, Adebiyi O, Agarwal A, Muller E, Quinn TC, Odim J, Huprikar S, Florman S, Massie AB, Tobian AAR, Segev DL. A prospective multicenter pilot study of HIV-pos-itive deceased donor to HIV-positive recipient kidney transplantation: HOPE in action. Am J Transplant. 2021;21(5):1754-1764. https://doi.org/10.1111/ajt.16205Durand CM, Zhang W, Brown DM, Yu S, Desai N, Redd AD, Bagnasco SM, Naqvi FF, Seaman S, Doby BL, Ostrander D, Bowring MG, Eby Y, Fernandez RE, Friedman-Moraco R, Turgeon N, Stock P, Chin-Hong P, Mehta S, Stosor V, Small CB, Gupta G, Mehta SA, Wolfe CR, Husson J, Gilbert A, Cooper M, Adebiyi O, Agarwal A, Muller E, Quinn TC, Odim J, Huprikar S, Florman S, Massie AB, Tobian AAR, Segev DL. A prospective multicenter pilot study of HIV-pos-itive deceased donor to HIV-positive recipient kidney transplantation: HOPE in action. Am J Transplant. 2021;21(5):1754-1764. https://doi.org/10.1111/ajt.16205Durand CM, Segev D, Sugarman J. Realizing HOPE: The ethics of organ transplantation from HIV-positive donors. Ann Intern Med. 2016;165(2):138-142. https://doi.org/10.7326/M16-0560Durand CM, Segev D, Sugarman J. Realizing HOPE: The ethics of organ transplantation from HIV-positive donors. Ann Intern Med. 2016;165(2):138-142. https://doi.org/10.7326/M16-0560Seaman SM, Van Pilsum Rasmussen SE, Nguyen AQ, Halpern SE, You S, Waldram MM, Anjum SK, Bowring MG, Muzaale AD, Ostrander DB, Brown D, Massie AB, Tobian AAR, Henderson ML, Fletcher FE, Smith B, Chao A, Gorupati N, Prakash K, Aslam S, Lee DH, Kirchner V, Pruett TL, Haidar G, Hughes K, Malinis M, Trinh S, Segev DL, Sugarman J, Durand CM. Brief Report: Willingness to accept HIV-infected and increased infectious risk donor organs among transplant candidates living with HIV. J Acquir Immune Defic Syndr. 2020;85(1):88-92. https://doi.org/10.1097/QAI.0000000000002405Seaman SM, Van Pilsum Rasmussen SE, Nguyen AQ, Halpern SE, You S, Waldram MM, Anjum SK, Bowring MG, Muzaale AD, Ostrander DB, Brown D, Massie AB, Tobian AAR, Henderson ML, Fletcher FE, Smith B, Chao A, Gorupati N, Prakash K, Aslam S, Lee DH, Kirchner V, Pruett TL, Haidar G, Hughes K, Malinis M, Trinh S, Segev DL, Sugarman J, Durand CM. Brief Report: Willingness to accept HIV-infected and increased infectious risk donor organs among transplant candidates living with HIV. J Acquir Immune Defic Syndr. 2020;85(1):88-92. https://doi.org/10.1097/QAI.0000000000002405Locke JE, Mehta S, Reed RD, MacLennan P, Massie A, Nellore A, Durand C, Segev DL. A national study of outcomes among HIV-infected kidney transplant recipients. J Am Soc Nephrol. 2015;26(9):2222-2229. https://doi.org/10.1681/ASN.2014070726Locke JE, Mehta S, Reed RD, MacLennan P, Massie A, Nellore A, Durand C, Segev DL. A national study of outcomes among HIV-infected kidney transplant recipients. J Am Soc Nephrol. 2015;26(9):2222-2229. https://doi.org/10.1681/ASN.2014070726Joshi D, Agarwal K. Role of liver transplantation in human immunodeficiency virus positive patients. World J Gastroenterol. 2015; 21(43):12311-12321. https://doi.org/10.3748/wjg.v21.i43.12311Joshi D, Agarwal K. Role of liver transplantation in human immunodeficiency virus positive patients. World J Gastroenterol. 2015; 21(43):12311-12321. https://doi.org/10.3748/wjg.v21.i43.12311Chin-Hong P, Beatty G, Stock P. Perspectives on liver and kidney transplantation in the human immunodeficiency virus-infected patient. Infect Dis Clin North Am. 2013;27(2):459-471. https://doi.org/10.1016/j.idc.2013.02.010Chin-Hong P, Beatty G, Stock P. Perspectives on liver and kidney transplantation in the human immunodeficiency virus-infected patient. Infect Dis Clin North Am. 2013;27(2):459-471. https://doi.org/10.1016/j.idc.2013.02.010Botha J, Fabian J, Etheredge H, Conradie F, Tiemessen CT. HIV and solid organ transplantation: where are we now. Curr HIV/AIDS Rep. 2019;16(5):404-413. https://doi.org/10.1007/s11904-019-00460-7Botha J, Fabian J, Etheredge H, Conradie F, Tiemessen CT. HIV and solid organ transplantation: where are we now. Curr HIV/AIDS Rep. 2019;16(5):404-413. https://doi.org/10.1007/s11904-019-00460-7Harbell J, Terrault NA, Stock P. Solid organ transplants in HIV-infected patients. Curr HIV/AIDS Rep. 2013; 10(3): 217-225. https://doi.org/10.1007/s11904-013-0170-zHarbell J, Terrault NA, Stock P. Solid organ transplants in HIV-infected patients. Curr HIV/AIDS Rep. 2013; 10(3): 217-225. https://doi.org/10.1007/s11904-013-0170-zZheng X, Gong L, Xue W, Zeng S, Xu Y, Zhang Y, Hu X. Kidney transplant outcomes in HIV-positive patients: a systematic review and meta-analysis. AIDS Res Ther. 2019;16(1):37. https://doi.org/10.1186/s12981-019-0253-zZheng X, Gong L, Xue W, Zeng S, Xu Y, Zhang Y, Hu X. Kidney transplant outcomes in HIV-positive patients: a systematic review and meta-analysis. AIDS Res Ther. 2019;16(1):37. https://doi.org/10.1186/s12981-019-0253-zChen C, Wen X, Yadav A, Belviso N, Kogut S, McCauley J Outcomes in human immunodeficiency virus-infected recipients of heart transplants. Clin Transplant. 2019;33(1):e13440. https://doi.org/10.1111/ctr.13440.Chen C, Wen X, Yadav A, Belviso N, Kogut S, McCauley J Outcomes in human immunodeficiency virus-infected recipients of heart transplants. Clin Transplant. 2019;33(1):e13440. https://doi.org/10.1111/ctr.13440.Terrault NA, Roland ME, Schiano T, Dove L, Wong MT, Poordad F, Ragni MV, Barin B, Simon D, Olthoff KM, Johnson L, Stosor V, Jayaweera D, Fung J, Sherman KE, Subramanian A, Millis JM, Slakey D, Berg CL, Carlson L, Ferrell L, Stablein DM, Odim J, Fox L, Stock PG. Outcomes of liver transplant recipients with hepatitis C and human immunodeficiency virus coinfection. Liver Transpl. 2012;18(6):716-726. https://doi.org/10.1002/lt.23411Terrault NA, Roland ME, Schiano T, Dove L, Wong MT, Poordad F, Ragni MV, Barin B, Simon D, Olthoff KM, Johnson L, Stosor V, Jayaweera D, Fung J, Sherman KE, Subramanian A, Millis JM, Slakey D, Berg CL, Carlson L, Ferrell L, Stablein DM, Odim J, Fox L, Stock PG. Outcomes of liver transplant recipients with hepatitis C and human immunodeficiency virus coinfection. Liver Transpl. 2012;18(6):716-726. https://doi.org/10.1002/lt.23411Miro JM, Montejo M, Castells L, Rafecas A, Moreno S, Aguero F, Abradelo M, Miralles P, Torre-Cisneros J, Pedreira JD, Cordero E, de la Rosa G, Moyano B, Moreno A, Perez I, Rimola A. Outcome of HCV/HIV-coinfected liver transplant recipients: a prospective and multicenter cohort study. Am J Transplant. 2012;12:1866-1876. https://doi.org/10.1111/j.1600-6143.2012.04028.xMiro JM, Montejo M, Castells L, Rafecas A, Moreno S, Aguero F, Abradelo M, Miralles P, Torre-Cisneros J, Pedreira JD, Cordero E, de la Rosa G, Moyano B, Moreno A, Perez I, Rimola A. Outcome of HCV/HIV-coinfected liver transplant recipients: a prospective and multicenter cohort study. Am J Transplant. 2012;12:1866-1876. https://doi.org/10.1111/j.1600-6143.2012.04028.xКлинические рекомендации EASL: трансплантация печени. Европейская ассоциация по изучению печени (EASL). Journal of Hepatology. 2016;64:433-485.EASL clinical guidelines: liver transplantation. European Association for the Study of the Liver (EASL). Journal of Hepatology. 2016;64:433-485. (In Russ.).Донорство органов при положительном статусе ВИЧ. Официальный интернет-портал Минздрава России о профилактике ВИЧ/СПИД. Доступно на: https://ospide.ru/way/donorstvo-organov-pri-polozhitelnom-statusevich (дата обращения: 24.01.2022).Organ donation with HIV positive status. Official Internet portal of the Ministry of Health of Russia on HIV/AIDS prevention. Available at: https://o-spide.ru/way/donorstvo-organov-pri-polozhitelnom-statuse-vich (date accessed: 24.01.2022). (In Russ.).Неабсолютное противопоказание: отношение к “ВИЧ-пересадкам” в России и мире. Доступно на: https://rustransplant.com/neabsolyutnoe-protivopokazanieotnoshenie-k-vich-peresadkam-v-rossii-i-mire/ (дата обращения: 24.01.2022).Non-absolute contraindication: attitude towards “HIV transplants” in Russia and the world. Available at: https://rustransplant.com/neabsolyutnoe-protivopokazanie-otnoshenie-k-vich-peresadkam-v-rossii-i-mire/ (date accessed: 24.01.2022). (In Russ.).Профессиональная ассоциация: Общероссийская общественная организация трансплантологов «Российское трансплантологическое общество». Клинические рекомендации Трансплантация печени, наличие транс плантированной печени, отмирание и отторжение трансплантата печени. 2020:1-95. https://transpl.ru/upload/medialibrary/0cb/0cbeb29cc22aa941f9d1a9f4ed11dd23.pdfProfessional association: All-Russian Public Organization of Transplantologists "Russian Transplant Society". Clinical recommendations Liver transplantation, the presence of a transplanted liver, death and rejection of the liver transplant. 2020:1-95. (In Russ.). https://transpl.ru/upload/medialibrary/0cb/0cbeb29cc22aa941f9d1a9f4ed11dd23.pdfSimonds RJ, Holmberg SD, Hurwitz RL, Coleman TR, Bottenfield S, Conley LJ, Kohlenberg SH, Castro KG, Dahan BA, Schable CA, Rayfield MA, Rogers MF. Transmission of human immunodeficiency virus type 1 from a seronegative organ and tissue donor. N Engl J Med. 1992;326(11):726-732. https://doi.org/10.1056/NEJM199203123261102Simonds RJ, Holmberg SD, Hurwitz RL, Coleman TR, Bottenfield S, Conley LJ, Kohlenberg SH, Castro KG, Dahan BA, Schable CA, Rayfield MA, Rogers MF. Transmission of human immunodeficiency virus type 1 from a seronegative organ and tissue donor. N Engl J Med. 1992;326(11):726-732. https://doi.org/10.1056/NEJM199203123261102Simonds RJ. HIV transmission by organ and tissue transplantation. AIDS. 1993;7(suppl. 2):S35-S38. https://doi.org/10.1097/00002030-199311002-00008Simonds RJ. HIV transmission by organ and tissue transplantation. AIDS. 1993;7(suppl. 2):S35-S38. https://doi.org/10.1097/00002030-199311002-00008Mitra CS. Human immunodeficiency virus infection in a renal transplant recipient. Indian J Nephrol. 2004;14:25-27.Mitra CS. Human immunodeficiency virus infection in a renal transplant recipient. Indian J Nephrol. 2004;14:25-27.Ahn J, Cohen SM. Transmission of human immunodeficiency virus and hepatitis C virus through liver transplantation. Liver Transpl. 2008;14(11):1603-1608. https://doi.org/10.1002/lt.21534Ahn J, Cohen SM. Transmission of human immunodeficiency virus and hepatitis C virus through liver transplantation. Liver Transpl. 2008;14(11):1603-1608. https://doi.org/10.1002/lt.21534Borchi B, Ambu S, Bresci S, Zanazzi M, Salvadori M, Leoncini F. Case report: HIV infection from a kidney transplant. Transplant Proc. 2010;42(6):2267-2269. https://doi.org/10.1016/j.transproceed.2010.05.026Borchi B, Ambu S, Bresci S, Zanazzi M, Salvadori M, Leoncini F. Case report: HIV infection from a kidney transplant. Transplant Proc. 2010;42(6):2267-2269. https://doi.org/10.1016/j.transproceed.2010.05.026Mukhopadhyay P, Kumar V, Rath M, Kohli HS, Jha V, Sakhuja V. Transmission of human immunodeficiency virus infection by renal transplantation. Indian J Nephrol. 2012;22:133-135. https://doi.org/10.4103/0971-4065.97135Mukhopadhyay P, Kumar V, Rath M, Kohli HS, Jha V, Sakhuja V. Transmission of human immunodeficiency virus infection by renal transplantation. Indian J Nephrol. 2012;22:133-135. https://doi.org/10.4103/0971-4065.97135Lin S-N, Tsai M-K, Luo C-Y, Lee C-Y, Hu R-H, Lee JM, Lai H-S. Outcomes of solid organ transplantation from an HIV positive donor to negative recipients. Am J Transplant. 2016;16(suppl. 3). https://atcmeetingabstracts.com/abstract/outcomes-of-solid-organ-transplantation-from-an-hiv-positive-donor-to-negative-recipients.Lin S-N, Tsai M-K, Luo C-Y, Lee C-Y, Hu R-H, Lee JM, Lai H-S. Outcomes of solid organ transplantation from an HIV positive donor to negative recipients. Am J Transplant. 2016;16(suppl. 3). https://atcmeetingabstracts.com/abstract/outcomes-of-solid-organ-transplantation-from-an-hiv-positive-donor-to-negative-recipients.

The authors declare that there are no conflicts of interest present.