spracticeХирургическая практикаSurgical practice (Russia)2223-2427АНО "Консорциум "Медицинская техника"10.38181/2223-2427-2021-2-48-60spractice-226Research ArticleСтатьиПЕРВИЧНО-МНОЖЕСТВЕННЫЕ СИНХРОННЫЕ ЗЛОКАЧЕСТВЕННЫЕ ОПУХОЛИ СИГМОВИДНОЙ КИШКИ И МОЛОЧНОЙ ЖЕЛЕЗЫ В СОЧЕТАНИИ С МЕНИНГИОМОЙ СПИННОГО МОЗГАMULTIPLE PRIMARY SYNCHRONOUS NEOPLASMS OF THE SIGMOID COLON AND BREAST IN COMBINATION WITH SPINAL CORD MENINGIOMA. CLINICAL CASEhttps://orcid.org/0000-0002-6569-7078АгаповМ. А.AgapovM. A.

доктор мед. наук, профессор, профессор кафедры хирургии 

ул. Ленинские Горы, д. 1, 119991, Москва; Ломоносовский проспект, д. 27 к. 10, 119991, Москва

PhD, Professor of the Department of Surgery

Leninskie Gory St., 1, 119991, Moscow; Lomonosovsky Prospect, 27/10, Moscow, 119192

https://orcid.org/0000-0002-9460-8935ДонченкоК. А.DonchenkoK. A.

врач-хирург отделения хирургии №1 

Ломоносовский проспект, д. 27 к. 10, 119991, Москва

Lomonosovsky Prospect, 27/10, Moscow, 119192

https://orcid.org/0000-0003-2631-7631КубышкинВ. А.KubyshkinV. A.

д.м.н., академик РАН, заведующий кафедрой хирургии

ул. Ленинские Горы, д. 1, 119991, Москва

PhD, academician of RSA, Head of the Surgery department

Leninskie Gory St., 1, 119991, Moscow

https://orcid.org/0000-0003-0352-2317КакоткинВ. В.KakotkinV. V.

врач-хирург отделения хирургии №1

Ломоносовский проспект, д. 27 к. 10, 119991, Москва

Department of Surgery №1

Lomonosovsky Prospect, 27/10, Moscow, 119192

axtroz4894@gmail.comhttps://orcid.org/0000-0001-7681-3073КащеевА. А.KasheevA. A.

к.м.н., руководитель отделения нейрохирургии

Ломоносовский проспект, д. 27 к. 10, 119991, Москва

Lomonosovsky Prospect, 27/10, Moscow, 119192

https://orcid.org/0000-0001-9208-2987ПолторакоЕ. Н.PoltorakoE. N.

врач отделения нейрохирургии

Ломоносовский проспект, д. 27 к. 10, 119991, Москва

Lomonosovsky Prospect, 27/10, Moscow, 119192

https://orcid.org/0000-0002-7212-9765СигалеваТ. В.SigalevaT. V.

врач отделения нейрохирургии

Ломоносовский проспект, д. 27 к. 10, 119991, Москва

Lomonosovsky Prospect, 27/10, Moscow, 119192

https://orcid.org/0000-0003-4140-7985БондарьС. В.BondarS. V.

врач отделения нейрохирургии

Ломоносовский проспект, д. 27 к. 10, 119991, Москва

Lomonosovsky Prospect, 27/10, Moscow, 119192

https://orcid.org/0000-0002-4213-9030БритиковаМ. В.BritikovaM. V.

руководитель отделения медицинской реабилитации

Ломоносовский проспект, д. 27 к. 10, 119991, Москва

Lomonosovsky Prospect, 27/10, Moscow, 119192

Московский государственный университет имени М.В. Ломоносова, факультет фундаментальной медицины (МГУ имени М.В. Ломоносова); Медицинский научно-образовательный центр МГУ имени М.В. ЛомоносоваРоссияFederal State Budget Educational Institution of Higher Education M.V. Lomonosov Moscow State University (Lomonosov MSU); Medical Research Educational Center, Lomonosov Moscow State UniversityRussian FederationМедицинский научно-образовательный центр МГУ имени М.В. ЛомоносоваРоссияMedical Research Educational Center, Lomonosov Moscow State UniversityRussian FederationМосковский государственный университет имени М.В. Ломоносова, факультет фундаментальной медицины (МГУ имени М.В. Ломоносова)РоссияFederal State Budget Educational Institution of Higher Education M.V. Lomonosov Moscow State University (Lomonosov MSU)Russian Federation202113082021024860Copyright © Агапов М.А., Донченко К.А., Кубышкин В.А., Какоткин В.В., Кащеев А.А., Полторако Е.Н., Сигалева Т.В., Бондарь С.В., Бритикова М.В., 20212021Агапов М.А., Донченко К.А., Кубышкин В.А., Какоткин В.В., Кащеев А.А., Полторако Е.Н., Сигалева Т.В., Бондарь С.В., Бритикова М.В.Agapov M.A., Donchenko K.A., Kubyshkin V.A., Kakotkin V.V., Kasheev A.A., Poltorako E.N., Sigaleva T.V., Bondar S.V., Britikova M.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.spractice.ru/jour/article/view/226

Общая частота первично-множественных онкологических заболеваний колеблется от 2,4% до 17%. Основные причины возникновения первичномножественных заболеваний включают факторы, связанные с образом жизни пациента, экологические и генетические факторы, а также факторы, связанные с проведенным комплексным лечением ранее выявленных злокачественных заболеваний.

Мы демонстрируем клинический случай лечения пациентки с синхронным первично-множественным раком сигмовидной кишки и молочной железы в сочетании с менингиомой спинного мозга. Интересен факт возможной связи между менингиомой и раком молочной железы. Так, риск возникновения менингиом у женщин, перенесших рак молочной железы, и риск рака молочной железы у женщин с менингиомой в анамнезе, умеренно повышен (RR = 1,40-1,64 и 1,54 соответственно). Данная двусторонняя зависимость может быть следствием общих факторов риска и частичного совпадения генно-средовых взаимодействий, определяющих туморогенез.

Необходимы дальнейшие исследования, чтобы лучше определить проблемы профилактики, скрининга, диагностики, лечения и безрецидивной выживаемости. Важно, чтобы пациенты с диагнозом «рак» имели информацию о возможных поздних и долгосрочных последствиях лечения и их симптомах, а также о возможных признаках рецидива и появления вторичных опухолей. Важно, чтобы пролеченные по поводу злокачественных новообразований пациенты следовали рекомендациям по профилактике рака и раннему выявлению среди населения в целом, включая отказ от курения, физическую активность, питание и диету, здоровый вес и все стандартные скрининговые обследования на рак.

The incidence of multiple primary oncological diseases ranges from 2.4% to 17%. The main causes of primary multiple diseases include factors related to the patient's lifestyle, environmental and genetic factors, as well as factors related to the comprehensive treatment of previously identified malignant diseases.

We demonstrate a clinical case of treatment of a patient with synchronous primary multiple cancer of the sigmoid colon and breast in combination with spinal cord meningioma. An interesting fact is the possible correlation between meningioma and breast cancer. Thus, the risk of meningioma in women who have had breast cancer and the risk of breast cancer in women with a history of meningioma is moderately increased (RR = 1.40-1.64 and 1.54, respectively). This two-way statistical association may be a consequence of common risk factors and a partial coincidence of gene-environmental interactions that determine carcinogenesis. Further research is needed to identify problems of prevention, screening, diagnosis, treatment and disease-free survival. It is important that patients diagnosed with cancer have information about possible late and long-term consequences of treatment and its symptoms, as well as possible signs of relapse and the appearance of secondary tumors. It is important that patients receiving treatment for malignant neoplasms follow the recommendations for cancer prevention and early detection, including smoking cessation, physical activity, nutrition and diet, a healthy weight and all standard cancer screening tests.

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The authors declare that there are no conflicts of interest present.