spracticeХирургическая практикаSurgical practice (Russia)2223-2427АНО "Консорциум "Медицинская техника"10.38181/2223-2427-2020-3-53-58spractice-182Research ArticleСтатьиПАРАЗИТАРНЫЙ АБСЦЕСС КАК СЛУЧАЙНАЯ ГИСТОЛОГИЧЕСКАЯ НАХОДКА ПРИ ЛЕЧЕНИИ РАКА СИГМОВИДНОЙ КИШКИPARASITIC ABSCESS AS AN INCIDENTAL HISTOLOGICAL FINDING IN THE TREATMENT OF SIGMOID COLON CANCERhttps://orcid.org/0000-0002-6359-0998ГаллямовЭ. А.GalliamovE. A.

Галлямов Эдуард Абдулхаевич — д. м. н., профессор, заведующий кафедрой общей хирургии

ул. Ленинские Горы, д. 1, 119991, Москва, Российская Федерация

Большая Пироговская ул., д. 2, стр. 4, 119435, Москва, Российская Федерация

Eduard A. Galliamov — MD, Professor, Head of the Department of General Surgery

Leninskie Gory St., 1, 119991, Moscow, Russian Federation

Bolshaya Pirogovskaya St., 19/1, 119146, Moscow, Russian Federation

gal_svetlana@mail.ruhttps://orcid.org/0000-0002-6569-7078АгаповМ. А.AgapovM. A.

Агапов Михаил Андреевич — д. м. н., профессор кафедры хирургии ФФМ

ул. Ленинские Горы, д. 1, 119991, Москва, Российская Федерация

Mikhail A. Agapov — PhD, Professor at the Department of Surgery

Leninskie Gory St., 1, 119991, Moscow, Russian Federation

getinfo911@mail.ruhttps://orcid.org/0000-0001-5074-3513МальковП. Г.Mal’kovP. G.

Мальков Павел Георгиевич — д. м. н., профессор, заведующий отделом клинической патологии МНОЦ

ул. Ленинские Горы, д. 1, 119991, Москва, Российская Федерация

Pavel G. Mal’kov — MD, Professor, Head of the Department of Clinical Patology of the Medical Research Educational Center

Leninskie Gory St., 1, 119991, Moscow, Russian Federation

pmalkov@mc.msu.ruhttps://orcid.org/0000-0003-2711-2400МаркарьянД. Р.MarkaryanD. R.

Маркарьян Даниил Рафаэлевич — к. м. н., доцент кафедры хирургии ФФМ

ул. Ленинские Горы, д. 1, 119991, Москва, Российская Федерация

Daniil R. Markaryan — PhD, Docent at the Department of Surgery

Leninskie Gory St., 1, 119991, Moscow, Russian Federation

dmarkaryan@gmail.comhttps://orcid.org/0000-0001-7848-6707ДаниловаН. В.DanilovaN. V.

Данилова Наталья Владимировна — к. м. н, с. н. с. отдела клинической патологии МНОЦ

ул. Ленинские Горы, д. 1, 119991, Москва, Российская Федерация

Natalya V. Danilova — PhD, Senior Researcher at the Department of Clinical Patology of the Medical Research Educational Center

Leninskie Gory St., 1, 119991, Moscow, Russian Federation

natalyadanilova@gmail.comhttps://orcid.org/0000-0003-0352-2317КакоткинВ. В.KakotkinV. V.

Какоткин Виктор Викторович — врач-хирург отделения хирургии №1 медицинского научно-образовательного центра

ул. Ленинские Горы, д. 1, 119991, Москва, Российская Федерация

Viktor V. Kakotkin — Surgeon at the Department of Surgery №1 of the Medical Research Educational Center

Leninskie Gory St., 1, 119991, Moscow, Russian Federation

axtroz4894@gmail.comhttps://orcid.org/0000-0001-6322-7016КазаченкоЕ. А.KazachenkoE. A.

Казаченко Екатерина Александровна — клинический ординатор кафедры хирургии ФФМ

ул. Ленинские Горы, д. 1, 119991, Москва, Российская Федерация

Ekaterina A. Kazachenko — Resident at the Department of Surgery of the Faculty of Medicine

Leninskie Gory St., 1, 119991, Moscow, Russian Federation

ekaterina.k.97@mail.ruhttps://orcid.org/0000-0002-2768-4305ЛукьяновА. М.LukyanovA. M.

Лукьянов Александр Максимович — клинический ординатор кафедры хирургии ФФМ

ул. Ленинские Горы, д. 1, 119991, Москва, Российская Федерация

Aleхander M. Lukyanov — Resident at the Department of Surgery of the Faculty of Medicine

Leninskie Gory St., 1, 119991, Moscow, Russian Federation

alexmaxl@mail.ruhttps://orcid.org/0000-0001-8564-8874ОлейниковаН. А.OleynikovaN. A.

Олейникова Нина Александровна – к.м.н, н.с. отдела клинической патологии МНОЦ

ул. Ленинские Горы, д. 1, 119991, Москва, Российская Федерация

Nina A. Oleynikova – PhD, Researcher of the Department of Clinical Pathology of the Medical Research Educational Center

Leninskie Gory St., 1, 119991, Moscow, Russian Federation

ale_x_05@mail.ruhttps://orcid.org/0000-0003-2631-7631КубышкинВ. А.KubyshkinV. A.

Кубышкин Валерий Алексеевич — д. м. н., академик РАН, заведующий кафедрой хирургии ФФМ

ул. Ленинские Горы, д. 1, 119991, Москва, Российская Федерация

Valery A. Kubyshkin — PhD, academician at RSA, Head of the Surgery Department

Leninskie Gory St., 1, 119991, Moscow, Russian Federation

VKubyshkin@mc.msu.ruМосковский государственный университет имени М. В. Ломоносова, факультет фундаментальной медицины (МГУ им. М.В. Ломоносова); Первый Московский государственный медицинский университет имени И. М. Сеченова (Сеченовский Университет)РоссияFederal State Budget Educational Institution of Higher Education M. V. Lomonosov Moscow State University (Lomonosov MSU); Federal State Autonomous Educational Institution of Higher Education I. M. Sechenov First Moscow State Medical University (Sechenov University)Russian FederationМосковский государственный университет имени М. В. Ломоносова, факультет фундаментальной медицины (МГУ им. М.В. Ломоносова)РоссияFederal State Budget Educational Institution of Higher Education M. V. Lomonosov Moscow State University (Lomonosov MSU)Russian Federation202004122020035358Copyright © Галлямов Э.А., Агапов М.А., Мальков П.Г., Маркарьян Д.Р., Данилова Н.В., Какоткин В.В., Казаченко Е.А., Лукьянов А.М., Олейникова Н.А., Кубышкин В.А., 20202020Галлямов Э.А., Агапов М.А., Мальков П.Г., Маркарьян Д.Р., Данилова Н.В., Какоткин В.В., Казаченко Е.А., Лукьянов А.М., Олейникова Н.А., Кубышкин В.А.Galliamov E.A., Agapov M.A., Mal’kov P.G., Markaryan D.R., Danilova N.V., Kakotkin V.V., Kazachenko E.A., Lukyanov A.M., Oleynikova N.A., Kubyshkin V.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.spractice.ru/jour/article/view/182

Введение: Высокая частота встречаемости колоректального рака во веем мире приводит к необходимости поиска не только эффективных методов лечения, но и факторов риска развития рака как такового и его худшего прогноза. Влияние многих генетических факторов, экологических особенностей и черт стиля жизни в контексте факторов риска колоректального рака уже доказано, поэтому в последнее время внимание исследователей устремлено на изучение микробиоты и, в частности, различных паразитарных заболеваний кишечника.Клинический случай: мы демонстрируем случайное обнаружение признаков паразитарной инвазии стенки толстой кишки в области злокачественного образования во время проведения гистологического исследования операционного материала у пациентки без отягощенного эпидемиологического анамнеза.Заключение: Необходимы дальнейшие исследования не только для подтверждения и обоснования роли микро- и макроорганизмов, населяющих кишечник в процессе развития онкологических заболеваний, но и для выявления отдельных звеньев патогенеза, патологических путей и сигнальных молекул, участвующих в канцерогенезе. Подобные исследования могут помочь расширить знания как о факторах риска и предикторах колоректального рака, так и о возможных местах приложения таргетной терапии.

Background: A high worldwide incidence of colorectal cancer defines the importance of search not only for effective treatment methods, but also for risk factors for the cancer development and its worst prognosis. The influence of many genetic factors, environmental characteristics and lifestyle features has already been proven, and recently the attention of researchers is being focused on the study of microbiota and, in particular, various parasitic intestinal diseases in the context of risk factors for colorectal cancer.Clinical case presentation: we demonstrate an incidental finding of parasitic invasion signs during the pathomorphological examination of the surgical specimen in a patient without an epidemiological history.Conclusion: Further studies are needed not only to confirm and substantiate the role of micro- and macroorganisms inhabiting the intestine in the development of oncological diseases, but also to identify individual links of pathogenesis, pathological pathways and signaling molecules involved in carcinogenesis. Research like this could help broaden knowledge about both the risk factors and predictors of colorectal cancer and the potential sites for targeted therapy.

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The authors declare that there are no conflicts of interest present.