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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">spractice</journal-id><journal-title-group><journal-title xml:lang="ru">Хирургическая практика</journal-title><trans-title-group xml:lang="en"><trans-title>Surgical practice (Russia)</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2223-2427</issn><publisher><publisher-name>АНО "Консорциум "Медицинская техника"</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">spractice-134</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group></article-categories><title-group><article-title>МУЛЬТИДИСЦИПЛИНАРНЫЙ ПОДХОД ПРИ ПЕРВИЧНО МНОЖЕСТВЕННОМ СИНХРОННОМ РАКЕ. КЛИНИЧЕСКИЙ СЛУЧАЙ</article-title><trans-title-group xml:lang="en"><trans-title>MULTIDISCIPLINARY APPROACH FOR PRIMARY MULTIPLE SYNCHRONOUS CANCER. CLINICAL CASE</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Галлямов</surname><given-names>Э. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Galliamov</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Галлямов Эдуард Абдулхаевич – д.м.н., профессор, заведующий кафедрой общей хирургии</p><p>Большая Пироговская ул., д. 19 стр. 1, 119146, Москва</p></bio><bio xml:lang="en"><p>Galliamov Eduard Abdulhaevich – MD, Professor, Head of the General Surgery Department</p><p>Bolshaya Pirogovskaya St., 19/1, 119146, Moscow</p></bio><email xlink:type="simple">gal_svetlana@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Агапов</surname><given-names>М. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Agapov</surname><given-names>M. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Агапов Михаил Андреевич - д.м.н., профессор кафедры хирургии ФФМ</p><p>ул. Ленинские Горы, д. 1, 119991, Москва</p></bio><bio xml:lang="en"><p>Agapov Mihail Andreevich – MD, Professor of the Department of Surgery</p><p>Leninskie Gory St., 1, 119991, Moscow</p></bio><email xlink:type="simple">getinfo911@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кубышкин</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Kubishkin</surname><given-names>V. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кубышкин Валерий Алексеевич – д.м.н., академик РАН, заведующий кафедрой хирургии</p><p>ул. Ленинские Горы, д. 1, 119991, Москва</p></bio><bio xml:lang="en"><p>Kubishkin Valery Alekseevich - MD, academician of RSA, Head of the Department of Surgery</p><p>Leninskie Gory St., 1, 119991, Moscow</p></bio><email xlink:type="simple">VKubyshkin@mc.msu.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Биктимиров</surname><given-names>Р. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Biktimirov</surname><given-names>R. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Биктимиров Рафаэль Габбасович – к.м.н., заведующий урологическим отделением</p><p>Микрорайон Новогорск, Химкинский городской округ, 141435, Московская о ласть</p></bio><bio xml:lang="en"><p>Biktimirov Rafael Gabbasovich – PhD, head of the Department of Urology</p><p>district Novogorsk, Himkinskij city district, 141435</p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Малахов</surname><given-names>П. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Malahov</surname><given-names>P. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Малахов Павел Сергеевич – заведующий отделением анестезиологии и реанимации Медицинского научно-образовательного центра</p><p>ул. Ленинские Горы, д. 1, 119991, Москва</p></bio><bio xml:lang="en"><p>Malahov Pavel Sergeevich - head of the Department of intensive care and anesthesiology of medical research and education center</p><p>Leninskie Gory St., 1, 119991, Moscow</p></bio><email xlink:type="simple">Pmalahov@mc.msu.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Какоткин</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kakotkin</surname><given-names>V. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Какоткин Виктор Викторович – клинический ординатор кафедры хирургии ФФМ</p><p>ул. Ленинские Горы, д. 1, 119991, Москва</p></bio><bio xml:lang="en"><p>Kakotkin Viktor Viktorovich - Resident of the Department of Surgery of the Faculty of Medicine</p><p>Leninskie Gory St., 1, 119991, Moscow</p></bio><email xlink:type="simple">axtroz4894@gmail.com</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Первый Московский государственный медицинский университет имени И.М. Сеченова (Сеченовский Университет)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University (Sechenov University)</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Московский государственный университет имени М.В. Ломоносова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal State Budget Educational Institution of Higher Education M.V. Lomonosov Moscow State University (Lomonosov MSU)</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Федеральное государственное бюджетное учреждение «Федеральный клинический центр высоких медицинских технологий Федерального медико-биологического агентства»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal State Institution "Federal Clinical Center of High Medical Technologies of the Federal Medical and Biological Agency"</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>23</day><month>04</month><year>2020</year></pub-date><volume>0</volume><issue>4</issue><fpage>62</fpage><lpage>67</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Галлямов Э.А., Агапов М.А., Кубышкин В.А., Биктимиров Р.Г., Малахов П.С., Какоткин В.В., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Галлямов Э.А., Агапов М.А., Кубышкин В.А., Биктимиров Р.Г., Малахов П.С., Какоткин В.В.</copyright-holder><copyright-holder xml:lang="en">Galliamov E.A., Agapov M.A., Kubishkin V.A., Biktimirov R.G., Malahov P.S., Kakotkin V.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.spractice.ru/jour/article/view/134">https://www.spractice.ru/jour/article/view/134</self-uri><abstract><p>Первично-множественные злокачественные новообразования довольно редко наблюдаются в клинической практике. Данные литературы у зывают на существование потенциальных факторов риска и в первую очередь генетических (синдромы Ли—Фраумени или Беквита—Видемана) для развития подобного рода заболеваний. Большинство обнаруживаемых в различных органах опухолей являются метахронными. В данной работе представлен вариант ведения пациента с первично-множественной неоплазией почки, предстательной железы и толстой кишки.</p><p>Больной (61 года) в плановом порядке поступил c диагноз: первично-множественный метахронный рак: рак левой почки сT3aN0M0, рак простаты сT1bN0M0, новообразование правых отделов ободочной кишки (тубулярная аденома с дисплазией III степени). Сопутствующая патология: ишемическая болезнь сердца, пароксизмальная форма фибрилляции предсердий, артериальная гипертензия. В клинике проведен мультидисциплинарный консилиум с привлечением онколога, хирурга-колопроктолога, уролога, радиолога, химиотерапевта, анестезиолога-реаниматолога, кардиолога, реабилитолога. Выполнена симультанная лапароскопическая простатэктомия, нефрэктомия, правосторонняя гемиколэктомия. Ведение пациента осуществляли согласно стандартным протоколам программы «быстрого восстановления».</p><p>Особенностью наблюдавшегося нами пациента являлось и то, что опухоль почки у него была выявлена еще 8 лет назад при амбулаторном обследовании, хотя этот факт нам не удалось подтвердить документально. Поскольку связь между почечно-клеточной карциномой и риском развития других злокачественных опухолей была показана в литературе, мы можем с большой долей вероятности предположить, что пациенты с почечно-клеточным раком имеют повышенный риск развития последующего первичного злокачественного новообразования.</p></abstract><trans-abstract xml:lang="en"><p>Primary multiple malignancies are rarely observed in clinical practice. Literature data indicate the existence of potential risk factors, primarily genetic ones (Li-Fraumeni or Beckwith–Wiedemann syndromes) for the development of such diseases. Most of the tumors found in various organs are metachronous. This paper presents a variant of managing a patient with primary multiple neoplasia of the kidney, prostate, and colon. The patient (61 years old) was admitted to clinic with diagnosis: primary multiple metachronous cancer: left kidney cancer cT3aN0M0, prostate cancer cT1bN0M0, neoplasm of the right colon (tubular adenoma with high-grade dysplasia). Comorbidities: coronary heart disease, paroxysmal form of atrial fibrillation, arterial hypertension. The clinic held a multidisciplinary consultation involving an oncologist, a coloproctologist, an urologist, a radiologist, a chemotherapist, an anesthesiologist, a cardiologist, and a rehabilitation specialist. Simultaneous laparoscopic prostatectomy, nephrectomy, and right hemicolectomy were performed. The patient was managed according to the standard protocols of the "rapid recovery" program.</p><p>Distinctive feature of the patient we observed was that the kidney tumor was detected 8 years ago during an outpatient examination, although we could not confirm this fact documented. Since the association between renal cell carcinoma and the risk of developing other malignant tumors has been shown in the literature, we can assume with high probability that patients with renal cell carcinoma have an increased risk of developing a subsequent primary malignancy.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>первично-множественный рак</kwd><kwd>рак простаты</kwd><kwd>рак почки</kwd><kwd>новообразование ободочной кишки</kwd></kwd-group><kwd-group xml:lang="en"><kwd>multiple primary neoplasia</kwd><kwd>prostate cancer</kwd><kwd>kidney cancer</kwd><kwd>colon neoplasia</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Rabbani F, Grimaldi G, Russo P. Multiple primary malignancies in renal cell carcinoma. J Urol. 1998; 160:1255-1259. https://doi.org/10.1016/S0022-5347(01)62510-2</mixed-citation><mixed-citation xml:lang="en">Rabbani F, Grimaldi G, Russo P. 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