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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">spractice</journal-id><journal-title-group><journal-title xml:lang="ru">Хирургическая практика</journal-title><trans-title-group xml:lang="en"><trans-title>Surgical practice (Russia)</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2223-2427</issn><publisher><publisher-name>АНО "Консорциум "Медицинская техника"</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.17238/issn2223-2427.2019.2.21-32</article-id><article-id custom-type="elpub" pub-id-type="custom">spractice-117</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group></article-categories><title-group><article-title>БАРИАТРИЧЕСКАЯ ХИРУРГИЯ – СОВРЕМЕННЫЙ ПУТЬ КОРРЕКЦИИ РЕПРОДУКТИВНОГО ЗДОРОВЬЯ У ЖЕНЩИН С МОРБИДНЫМ ОЖИРЕНИЕМ</article-title><trans-title-group xml:lang="en"><trans-title>BARIATRIC SURGERY – A MODERN WAY OF CORRECTION OF REPRODUCTIVE HEALTH IN WOMEN WITH MORBID OBESITY</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Елагин</surname><given-names>И. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Elagin</surname><given-names>I. B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Елагин Илья Борисович – заведующий отделением хирургии</p><p>Ставропольская ул., домовл. 23, корп.1Моб.тел: + 7-925-000-05-55 </p></bio><bio xml:lang="en"><p>Elagin Ilya Borisovich - Head of the Surgery</p><p>Stavropolskaya St., dom. 23, building 1</p></bio><email xlink:type="simple">il.elagin@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Оразов</surname><given-names>М. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Orazov</surname><given-names>M. R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Оразов Мекан Рахимбердыевич – д.м.н., профессор кафедры акушерства и гинекологии с курсом перинатологии</p><p>ул. Миклухо-Маклая, д. 6, Москва</p></bio><bio xml:lang="en"><p>Orazov Mekan Rakhimberdievich – MD, Professor in the Department of obstetrics and gynecology with course of Perinatology the medical faculty, Medical Institute; the branch of specialization is obstetrics and gynecology</p><p>117198, Moscow, Miklukho - Maklaya str., h. 6</p></bio><email xlink:type="simple">omekan@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Харнас</surname><given-names>С. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Kharnas</surname><given-names>S. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Харнас Сергей Саулович – д.м.н., профессор кафедры факультетской хирургии №1</p><p>119048, г. Москва, ул. Трубецкая, д. 8</p></bio><bio xml:lang="en"><p>Kharnas Sergey Saulovich – MD, professor of the Department of Faculty Surgery No. 1</p><p>119048, Moscow, st. Trubetskaya, d. 8</p></bio><email xlink:type="simple">harnas@mail.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хамошина</surname><given-names>М. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Khamoshina</surname><given-names>M. B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Хамошина Марина Борисовна – д.м.н., профессор кафедры акушерства и гинекологии с курсом перинатологии</p><p>ул. Миклухо-Маклая, д. 6, Москва, Россия, 117198</p></bio><bio xml:lang="en"><p>Khamoshina Marina Borisovna - MD, professor of the Department of Obstetrics and Gynecology with a course of perinatology</p><p>st. Miklukho-Maklaya, 6, Moscow, Russia, 117198</p></bio><email xlink:type="simple">mbax999@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Токтар</surname><given-names>Л. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Toktar</surname><given-names>L. R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Токтар Лилия Равильевна – к.м.н., доцент кафедры акушерства и гинекологии с курсом перинатологии медицинского факультета, Медицинского института; отрасль специализации - акушерство и гинекология</p><p>117198, Россия, Москва, ул. Миклухо-Маклая, д.6</p></bio><bio xml:lang="en"><p>Toktar Liliya Ravilievna – candidate of medical sciences, associate professor of the Department of Obstetrics and Gynecology with a course of perinatology; specialization industry – obstetrics and gynecology</p><p>117198, Moscow, ul. Miklukho-Maklaya, 6</p></bio><email xlink:type="simple">toktarly@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ботов</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Botov</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ботов Алексей Андреевич – врач-хирург отделения хирургии, аспирант кафедры общей хирургии МГМСУ им. А. И. Евдокимова</p><p>Ставропольская ул., домовл. 23, корп.1127473 , г. Москва, ул. Делегатская, д. 20/1</p></bio><bio xml:lang="en"><p>Botov Aleksey Andreevich – doctor-surgeon, postgraduate of the Department of general surgery, A.I. Evdokimov Moscow State University of Medicine and Dentistry</p><p>Stavropolskaya St., dom. 23, building 1127473, Moscow, Delegatskaya St., 20/1 </p></bio><email xlink:type="simple">botov48@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>НУЗ «Дорожная клиническая больница имени Н.А. Семашко на станции Люблино ОАО «РЖД»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>NUZ “Road Clinical Hospital named after N.A. Semashko at the Lyublino station of JSC Russian Railways</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГАОУ ВО «Российский университет дружбы народов»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>RUDN University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>The I.M. Sechenov First Moscow State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>17</day><month>04</month><year>2020</year></pub-date><volume>0</volume><issue>2</issue><fpage>21</fpage><lpage>32</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Елагин И.Б., Оразов М.Р., Харнас С.С., Хамошина М.Б., Токтар Л.Р., Ботов А.А., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Елагин И.Б., Оразов М.Р., Харнас С.С., Хамошина М.Б., Токтар Л.Р., Ботов А.А.</copyright-holder><copyright-holder xml:lang="en">Elagin I.B., Orazov M.R., Kharnas S.S., Khamoshina M.B., Toktar L.R., Botov A.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.spractice.ru/jour/article/view/117">https://www.spractice.ru/jour/article/view/117</self-uri><abstract><p>Настоящий обзор посвящен проблеме морбидного ожирения и нарушениям репродуктивной функции у женщин фертильного возраста. Справедливости ради следует констатировать факт, что масштабы распространения ожирения неуклонно увеличиваются во всем мире. Представлены современные данные литературы о распространённости, факторах риска, патогенезе и возможностях бариатрической хирургии в коррекции нарушений репродуктивного здоровья у женщин фертильного возраста.</p></abstract><trans-abstract xml:lang="en"><p>The present review is devoted to the problem of morbid obesity and reproductive disorders in women of fertile age. In fairness, we should mention the fact that the prevalence of obesity is steadily increasing worldwide. Presents recent data of literature on the prevalence, risk factors, pathogenesis and possibilities of bariatric surgery in the correction of reproductive disorders in women of fertile age.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>морбидное ожирение</kwd><kwd>репродуктивное здоровье</kwd><kwd>бариатрическая хирургия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>morbid obesity</kwd><kwd>reproductive health</kwd><kwd>bariatric surgery</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Аганезова Н.В. Ожирение и репродуктивное здоровье женщины // Акушерство и гинекология. 2016. No6. С.18-25.</mixed-citation><mixed-citation xml:lang="en">Aganezova N.V. Obesity and reproductive health of women. Akusherstvo and gynecology,2016, No6, рр.18-25. [In Russ].</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Дедов И.И. Проблема ожирения: от синдрома к заболеванию // Ожирение и метаболизм. 2006. No1(6). С.1-4.</mixed-citation><mixed-citation xml:lang="en">Dedov I.I. The problem of obesity: from syndrome to disease. Obesity and metabolism,2006, No1(6), рр.1-4. [In Russ].</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Дедов И.И., Мельниченко Г.А. Синдром поликистозных яичников // МИА. 2007.</mixed-citation><mixed-citation xml:lang="en">Dedov I.I., Melnichenko G.A. Polycystic ovary syndrome. ME Moscow,2007. [In Russ].</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Дедов И.И., Мельниченко Г.А., Шестакова М.В., Трошина Е.А. Лечение морбидного ожирения у взрослых // Ожирение и метаболизм. 2018. No15(1). С.53-70.</mixed-citation><mixed-citation xml:lang="en">Dedov I.I., Melnichenko G.A., Shestakova M.V., Troshina E.A. et al. Treatment of morbid obesity in adults. Obesity and metabolism,2018, No15(1), рр.53-70. [In Russ].</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Косыгина А.В. Новое в патогенезе ожирения: адипокины гормоны жировой ткани // Проблемы эндокринологии. 2009. No55(1). С.4450.</mixed-citation><mixed-citation xml:lang="en">Kosygina A.V. New in the pathogenesis of obesity: adipokines - hormones of adipose tissue. Problems of endocrinology,2009, No55(1), рр.4450. [In Russ].</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Кручинин Е.В., Аутлев К.М., Янин Е.Л. Изменения овариально-менструального цикла у пациенток с морбидным ожирением в результате бариатрических операций // Анналы хирургии. 2015. No3. C.24-8.</mixed-citation><mixed-citation xml:lang="en">Kruchinin E.V., Autlev K.M., Yanin E.L. Changes in the ovarianmenstrual cycle in patients with morbid obesity as a result of bariatric surgery // Annals of surgery. 2015.No3. C.24-8. [In Russ].</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Кузнецова И.В. Гиперпластические процессы эндометрия // Акушерство и гинекология. 2009. 48 c.</mixed-citation><mixed-citation xml:lang="en">Kuznetsova I.V. Endometrial hyperplastic processes. M., 2009,рр. 48 . [In Russ].</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Мычка В. Б., Верткин А. Л., Вардаев Л. И. и др. Консенсус экспертов по междисциплинарному подходу к ведению, диагностике и лечению больных с метаболическим синдромом // Кардиоваскулярная терапия и профилактика. 2013. No12(6). С.41–81.</mixed-citation><mixed-citation xml:lang="en">Mychka V. B., Vertkin A. L., Vardaev L. I. et al. Expert consensus on an interdisciplinary approach to the management, diagnosis and treatment of patients with metabolic syndrome. Cardiovascular therapy and prevention, 2013,No12 (6), рр.41–81.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Овсянникова Т.В., Боровкова Е.И., Шешукова Н.А., Куликов И.А. Современный взгляд на проблему избыточной массы тела и ожирения // Российский вестник акушера-гинеколога. 2010. No2(10). С.72-76.</mixed-citation><mixed-citation xml:lang="en">Ovsyannikova T.V., Borovkova E.I., Sheshukova N.A., Kulikov I.A. A modern view of the problem of overweight and obesity .Russian Bulletin of the Obstetrician-Gynecologist, 2010, No2 (10),рр.72-76.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Снегирев В.Ф. Место бариатрической хирургии в восстановлении репродуктивного здоровья женщины с ожирением // Archives of Obstetrics and Gynecology. 2016. No3(2). P.106-107.</mixed-citation><mixed-citation xml:lang="en">Snegirev V.F. The place of bariatric surgery in restoring the reproductive health of an obese woman .Archives of Obstetrics and Gynecology, 2016, No3 (2) ,рр.106-107.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Тиканова В.В., Кузнецова И.В. Взаимосвязь и коррекция обменно-эндокринных расстройств у женщин с нарушениями менструального цикла на фоне ожирения // Российский вестник акушерства и гинекологии. 2006. No6(3). С.12-17.</mixed-citation><mixed-citation xml:lang="en">Tikanova V.V., Kuznetsova I.V. The relationship and correction of metabolic and endocrine disorders in women with menstrual irregularities against the background of obesity.Russian Journal of Obstetrics and Gynecology,2006,No6 (3), рр.12-17.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Ткаченко Л. В., Свиридова Н. И., Складановская Т. В. Современное состояние проблемы избыточной массы тела и ожирения у женщин // Вестник ВолГМУ. 2017. В.4(64). С.3-7.</mixed-citation><mixed-citation xml:lang="en">Tkachenko L. V., Sviridova N. I., Skladanovskaya T. V. The current state of the problem of overweight and obesity in women .Vestnik VolGMU,2017, B.4 (64),рр.3-7.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Фишман М. Эффективность лапароскопического регулироемого бандажирование желудка у женщин с морбидным ожирением и метаболическим синдромом // Журналъ акушерства и женских болезней. 2008. No58(1). С.30-35.</mixed-citation><mixed-citation xml:lang="en">Fishman M. The effectiveness of laparoscopic adjustable gastric banding in women with morbid obesity and metabolic syndrome. Journal of Obstetrics and Women’s Diseases,2008,No58 (1), рр.30-35.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Чеботникова Т.В., Семичева Т.В. Терапевтические возможности метформина при восстановлении фертильности у пациенток с синдромом поликистозных яичников, обзор литературы // Вестник репродуктивного здоровья. 2008. Декабрь. С.13-24.</mixed-citation><mixed-citation xml:lang="en">Chebotnikova T.V., Semicheva T.V. The therapeutic possibilities of metformin in the restoration of fertility in patients with polycystic ovary syndrome, literature review.Reproductive Health Bulletin. 2008, рр.13-24.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Чернуха Г.Е., М.Р. Думановская. Современные представления о гиперплазии эндометрия (обзор литературы) // Акушерство и гинекология. 2013. No3. С.26-32.</mixed-citation><mixed-citation xml:lang="en">Chernukha G.E., M.R. Dumanovskaya. Modern views on endometrial hyperplasia (literature review) .Obstetrics and Gynecology. 2013. No3. S.26-32.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Abarca-Gómez L., Abdeen Z.A., Hamid Z.A., et al. Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128•9 million children, adolescents, and adults. The Lancet, 2017, V.390(10113),рр .2627-2642.</mixed-citation><mixed-citation xml:lang="en">Abarca-Gómez L., Abdeen Z.A., Hamid Z.A., et al. Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128•9 million children, adolescents, and adults. The Lancet, 2017, V.390(10113),рр .2627-2642.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Ahluwalia, J. S., Kuo H.-C., Chang P.-C., Sun P.L., Hung K.C., Huang, C.K. Standardized Technique of Laparoscopic Adjustable Gastric Banded Plication with 4-Year Results. Obesity Surgery, 2015, V.25(9) ,рр.1756–1757.</mixed-citation><mixed-citation xml:lang="en">Ahluwalia, J. S., Kuo H.-C., Chang P.-C., Sun P.L., Hung K.C., Huang, C.K. Standardized Technique of Laparoscopic Adjustable Gastric Banded Plication with 4-Year Results. Obesity Surgery, 2015, V.25(9) ,рр.1756–1757.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Alberti K.G., Zimmet P.Z., Shaw J. Metabolic syndrome – a new world-wide definition. A Consensus Statement from the International Diabetes Federation. Diabet,Med, 2006, No23(5), рр.469-80.</mixed-citation><mixed-citation xml:lang="en">Alberti K.G., Zimmet P.Z., Shaw J. Metabolic syndrome – a new world-wide definition. A Consensus Statement from the International Diabetes Federation. Diabet,Med, 2006, No23(5), рр.469-80.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Azziz R., Carmina E., Dewailly D. et al. Position statement: criteria for defining polycystic ovary syndrome as a predominantly hyperandrogenic syndrome: an Androgen Excess Society guideline. JCE&amp;M, 2006, V.91, рр.4237-4245.</mixed-citation><mixed-citation xml:lang="en">Azziz R., Carmina E., Dewailly D. et al. Position statement: criteria for defining polycystic ovary syndrome as a predominantly hyperandrogenic syndrome: an Androgen Excess Society guideline. JCE&amp;M, 2006, V.91, рр.4237-4245.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Boeing H. Obesity and cancer – the update 2013. Best Pract. Res. Clin. Endocrinol. Metab.,2013, No27(2), рр.219-27.</mixed-citation><mixed-citation xml:lang="en">Boeing H. Obesity and cancer – the update 2013. Best Pract. Res. Clin. Endocrinol. Metab.,2013, No27(2), рр.219-27.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Boza C., Gamboa C., Perez G., Crovari F., Escalona A., Pimentel, F. Laparoscopic adjustable gastric banding (LAGB): surgical results and 5-year follow-up. Surgical Endoscopy,2010, V.25(1), рр.292-297.</mixed-citation><mixed-citation xml:lang="en">Boza C., Gamboa C., Perez G., Crovari F., Escalona A., Pimentel, F. Laparoscopic adjustable gastric banding (LAGB): surgical results and 5-year follow-up. Surgical Endoscopy,2010, V.25(1), рр.292-297.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Budak E., Fernandez Sanchez M., Bellver J., Cervero A., Simon C., Pellicer A. Interactions of the hormones leptin, ghrelin, adiponectin, resistin, and PYY3-36 with the reproductive system. Fertil. Steril.,2006, No85(6), рр.1563–81.</mixed-citation><mixed-citation xml:lang="en">Budak E., Fernandez Sanchez M., Bellver J., Cervero A., Simon C., Pellicer A. Interactions of the hormones leptin, ghrelin, adiponectin, resistin, and PYY3-36 with the reproductive system. Fertil. Steril.,2006, No85(6), рр.1563–81.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Chabrolle C., Tosca L., Rame C., Lecomte P., Royere D., Dupont J. Adiponectin increases insulin-like growth factor I – induced progesterone and estradiol secretion in human granulosa cells. Fertil. Steril.,2009, No92(6), рр.1988–96.</mixed-citation><mixed-citation xml:lang="en">Chabrolle C., Tosca L., Rame C., Lecomte P., Royere D., Dupont J. Adiponectin increases insulin-like growth factor I – induced progesterone and estradiol secretion in human granulosa cells. Fertil. Steril.,2009, No92(6), рр.1988–96.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Chavarro J.E., Rich-Edwards J.W., Rosner B.A. A prospective study of dietary carbohydrate quantity and quality in relation to risk of ovulatory infertility. Eur. J. Clin. Nutr.,2009, No63(1), рр.78–86.</mixed-citation><mixed-citation xml:lang="en">Chavarro J.E., Rich-Edwards J.W., Rosner B.A. A prospective study of dietary carbohydrate quantity and quality in relation to risk of ovulatory infertility. Eur. J. Clin. Nutr.,2009, No63(1), рр.78–86.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Crujeiras A.B., Casanueva F.F. Obesity and the reproductive system disorders: epigenetics as a potential bridge. Hum. Reprod. Update,2014, No34(5),рр.123–36.</mixed-citation><mixed-citation xml:lang="en">Crujeiras A.B., Casanueva F.F. Obesity and the reproductive system disorders: epigenetics as a potential bridge. Hum. Reprod. Update,2014, No34(5),рр.123–36.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">De Pergola G., Tartagni M., d’Angelo F., Centoducati C., Guida P., Giorgino R. Abdominal fat accumulation, and not insulin resistance, is associated to oligomenorrhea in nonhyperandrogenic overweight/ obese women. J. Endocrinol. Invest. ,2009, No32(2), рр.98–101.</mixed-citation><mixed-citation xml:lang="en">De Pergola G., Tartagni M., d’Angelo F., Centoducati C., Guida P., Giorgino R. Abdominal fat accumulation, and not insulin resistance, is associated to oligomenorrhea in nonhyperandrogenic overweight/ obese women. J. Endocrinol. Invest. ,2009, No32(2), рр.98–101.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Dunaif A. Insulin resistance and the PCOS: mechanism and implications for pathogenesis. Endocr Rev.,1997, V.18., рр.774-800.</mixed-citation><mixed-citation xml:lang="en">Dunaif A. Insulin resistance and the PCOS: mechanism and implications for pathogenesis. Endocr Rev.,1997, V.18., рр.774-800.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Ed. Branca F. The challenge of obesity in the WHO European Region and the strategies for response. Repowt of WHO Regional Office for Europe. 2007 http://www.euro.who.int/document/E90711.pdf.</mixed-citation><mixed-citation xml:lang="en">Ed. Branca F. The challenge of obesity in the WHO European Region and the strategies for response. Repowt of WHO Regional Office for Europe. 2007 http://www.euro.who.int/document/E90711.pdf.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Epplein M., Reed S.D., Voight L F. et al. Risk of complex and atypical endometrial hyperplasia in relation to anthropometric measures and reproductive history. Am. J. Epidemiol,2008, V.168(6), рр.563-570.</mixed-citation><mixed-citation xml:lang="en">Epplein M., Reed S.D., Voight L F. et al. Risk of complex and atypical endometrial hyperplasia in relation to anthropometric measures and reproductive history. Am. J. Epidemiol,2008, V.168(6), рр.563-570.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">F. Xavier Pi-Sunyer, Diane M. Becker, Claude Bouchard, Richard A. Carleton et al. Clinical Guidelines on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults. The American Journal of Clinical Nutrition,1998, 68(4), рр.899–917.</mixed-citation><mixed-citation xml:lang="en">F. Xavier Pi-Sunyer, Diane M. Becker, Claude Bouchard, Richard A. Carleton et al. Clinical Guidelines on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults. The American Journal of Clinical Nutrition,1998, 68(4), рр.899–917.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Freedman D.M., Ron E., Ballard-Barbash R., et al. Body mass index and all-cause mortality in a nationwide US cohort. Int. J. Obes.,2006, V.30(5), рр.822-829.</mixed-citation><mixed-citation xml:lang="en">Freedman D.M., Ron E., Ballard-Barbash R., et al. Body mass index and all-cause mortality in a nationwide US cohort. Int. J. Obes.,2006, V.30(5), рр.822-829.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Fried M., Yumuk V., Oppert J.-M. et al. Interdisciplinary European Guidelines on Metabolic and Bariatric Surgery. Obesity Facts, 2013, V.6(5), рр.449-468.</mixed-citation><mixed-citation xml:lang="en">Fried M., Yumuk V., Oppert J.-M. et al. Interdisciplinary European Guidelines on Metabolic and Bariatric Surgery. Obesity Facts, 2013, V.6(5), рр.449-468.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Geliebter A., Carnell S., Gluck M.E. Cortisol and ghrelin concentrations following a cold pressor stress test in owerweight individuals with and without. Night Eating. Int. J. Obes, 2013, No37(8), рр.1104–8.</mixed-citation><mixed-citation xml:lang="en">Geliebter A., Carnell S., Gluck M.E. Cortisol and ghrelin concentrations following a cold pressor stress test in owerweight individuals with and without. Night Eating. Int. J. Obes, 2013, No37(8), рр.1104–8.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Gillon S., Jeanes Y. M., Andersen J. R., Våge V. Micronutrient Status in Morbidly Obese Patients Prior to Laparoscopic Sleeve Gastrectomy and Micronutrient Changes 5 years Post-surgery. Obesity Surgery, 2016, V.27(3), рр.606-612.</mixed-citation><mixed-citation xml:lang="en">Gillon S., Jeanes Y. M., Andersen J. R., Våge V. Micronutrient Status in Morbidly Obese Patients Prior to Laparoscopic Sleeve Gastrectomy and Micronutrient Changes 5 years Post-surgery. Obesity Surgery, 2016, V.27(3), рр.606-612.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Global Health Risks: mortality and burden of disease attributable to selected major risks. Report of the World Health Organization. 2009.</mixed-citation><mixed-citation xml:lang="en">Global Health Risks: mortality and burden of disease attributable to selected major risks. Report of the World Health Organization. 2009.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Goodman NF. Polycystic Ovary Syndrome Writing Committee American Association of Clinical Endocrinologists position statements on metabolic and cardiovascular consequences of PCOS. Endocr Pract, 2005, V.11, . рр.126-134.</mixed-citation><mixed-citation xml:lang="en">Goodman NF. Polycystic Ovary Syndrome Writing Committee American Association of Clinical Endocrinologists position statements on metabolic and cardiovascular consequences of PCOS. Endocr Pract, 2005, V.11, . рр.126-134.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Guh D.P., Zhang W., Bansback N., et al. The incidence of comorbidities related to obesity and overweight: A systematic review and meta-analysis. BMC Public Health, 2009, V.9(1).</mixed-citation><mixed-citation xml:lang="en">Guh D.P., Zhang W., Bansback N., et al. The incidence of comorbidities related to obesity and overweight: A systematic review and meta-analysis. BMC Public Health, 2009, V.9(1).</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Gul O.O., Cander S., Gul B., Ackgoz E., Sarandol E., Ersoy C. Evaluation of insulin resistance and plasma levels for visfatin and resistin in obese and non – obese patients with polycystic ovary syndrome. Eur. Cytokine Netw, 2015, No26(4), рр.73–8.</mixed-citation><mixed-citation xml:lang="en">Gul O.O., Cander S., Gul B., Ackgoz E., Sarandol E., Ersoy C. Evaluation of insulin resistance and plasma levels for visfatin and resistin in obese and non – obese patients with polycystic ovary syndrome. Eur. Cytokine Netw, 2015, No26(4), рр.73–8.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Health in the European Union: Trends and Analysis. Report of the WHO European Observatory on Health Systems. 2009. Observatory Studies Series No19.</mixed-citation><mixed-citation xml:lang="en">Health in the European Union: Trends and Analysis. Report of the WHO European Observatory on Health Systems. 2009. Observatory Studies Series No19.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Heidemann C., Sun Q., van Dam R.M., Meigs J.B., Zhang C., Tworoger S.S., et al. Total and highmolecular – weight adiponectin and resistin in relation to the risk for type 2 diabetes in women.Ann. Intern, Med. ,2008, No149(5), рр.307–16.</mixed-citation><mixed-citation xml:lang="en">Heidemann C., Sun Q., van Dam R.M., Meigs J.B., Zhang C., Tworoger S.S., et al. Total and highmolecular – weight adiponectin and resistin in relation to the risk for type 2 diabetes in women.Ann. Intern, Med. ,2008, No149(5), рр.307–16.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Hsueh A.J., Billig H., Tsafriri A. Ovarian follicle atresia: a hormonally controlled apoptotic process. Endocr Rev, 1994, V.15, рр.707-724.</mixed-citation><mixed-citation xml:lang="en">Hsueh A.J., Billig H., Tsafriri A. Ovarian follicle atresia: a hormonally controlled apoptotic process. Endocr Rev, 1994, V.15, рр.707-724.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">James W.F.T. Epidemiology of obesity. Internat J Obes, 1992, V.16(2), рр. 23-6.</mixed-citation><mixed-citation xml:lang="en">James W.F.T. Epidemiology of obesity. Internat J Obes, 1992, V.16(2), рр. 23-6.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Jungheim E.S., Travieso J.L., Hopeman M.M. Weighing the impact of obesity on female reproductive function and fertility. Nutr. Rev, 2013, No71, рр.3–8.</mixed-citation><mixed-citation xml:lang="en">Jungheim E.S., Travieso J.L., Hopeman M.M. Weighing the impact of obesity on female reproductive function and fertility. Nutr. Rev, 2013, No71, рр.3–8.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Kannel W.B., D’Agostino R.B., Cobb J.L. Effect of weight on cardiovascular disease. The American Journal of Clinical Nutrition,1996, V.63(3), рр.419-422.</mixed-citation><mixed-citation xml:lang="en">Kannel W.B., D’Agostino R.B., Cobb J.L. Effect of weight on cardiovascular disease. The American Journal of Clinical Nutrition,1996, V.63(3), рр.419-422.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Koiou E., Tziomalos K., Katsikis I., Kandaraki E.A., Kalaitzakis E., Delkos D. et al. Weight loss significantly reduces serum lipocalin – 2 levels in overweight and obese women with polycystic ovary syndrome. Gynecol. Endocrinol,2012, No28(1), рр.20–4.</mixed-citation><mixed-citation xml:lang="en">Koiou E., Tziomalos K., Katsikis I., Kandaraki E.A., Kalaitzakis E., Delkos D. et al. Weight loss significantly reduces serum lipocalin – 2 levels in overweight and obese women with polycystic ovary syndrome. Gynecol. Endocrinol,2012, No28(1), рр.20–4.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Lars Sjöström. Review of the key results from the Swedish Obese Subjects (SOS) trial - a prospective controlled intervention study of bariatric surgery. J Intern Med, 2013, V.273(3), рр.219-34. 50.</mixed-citation><mixed-citation xml:lang="en">Lars Sjöström. Review of the key results from the Swedish Obese Subjects (SOS) trial - a prospective controlled intervention study of bariatric surgery. J Intern Med, 2013, V.273(3), рр.219-34. 50.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Lenz M, Richter T, Muhlhauser I. The morbidity and mortality associated with overweight and obesity in adulthood: a systematic review. Dtsch Arztebl Int.,2009, V.106(40), рр.641-648.</mixed-citation><mixed-citation xml:lang="en">Lenz M, Richter T, Muhlhauser I. The morbidity and mortality associated with overweight and obesity in adulthood: a systematic review. Dtsch Arztebl Int.,2009, V.106(40), рр.641-648.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Loret de Mola J.R. Obesity and its relationship to infertility in men and women. Obstet Gynecol Clin North Am.,2009, V.36(2), рр.333-346.</mixed-citation><mixed-citation xml:lang="en">Loret de Mola J.R. Obesity and its relationship to infertility in men and women. Obstet Gynecol Clin North Am.,2009, V.36(2), рр.333-346.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Magro D. O., Ueno M., Coelho-Neto J. de S., Callejas-Neto F., Pareja J. C., Cazzo E. Long-term weight loss outcomes after banded Roux-en-Y gastric bypass: a prospective 10-year follow-up study. Surgery for Obesity and Related Diseases, 2018, V.14(7), рр.910-917.</mixed-citation><mixed-citation xml:lang="en">Magro D. O., Ueno M., Coelho-Neto J. de S., Callejas-Neto F., Pareja J. C., Cazzo E. Long-term weight loss outcomes after banded Rouxen-Y gastric bypass: a prospective 10-year follow-up study. Surgery for Obesity and Related Diseases, 2018, V.14(7), рр.910-917.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Mantzoros C.S. Leptin in relation to the lipodystrophyassociated metabolic syndrome. Diabetes Metab J., 2012 , No36(3), рр.81-9.</mixed-citation><mixed-citation xml:lang="en">Mantzoros C.S. Leptin in relation to the lipodystrophyassociated metabolic syndrome. Diabetes Metab J., 2012 , No36(3), рр.81-9.</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Melin I., Reynisdottir S., Berglund L., Zamfir M., Karlström B. Conservative treatment of obesity in an academic obesity unit. Long-term outcome and drop-out. Eat Weight Disord, 2006, V.11(1), рр.22-30.</mixed-citation><mixed-citation xml:lang="en">Melin I., Reynisdottir S., Berglund L., Zamfir M., Karlström B. Conservative treatment of obesity in an academic obesity unit. Long-term outcome and drop-out. Eat Weight Disord, 2006, V.11(1), рр.22-30.</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Metwally M., Li T.C., Ledger W.L. The impact of obesity on female reproductive function. Obes. Rev, 2007, No8(6), рр.515-23.</mixed-citation><mixed-citation xml:lang="en">Metwally M., Li T.C., Ledger W.L. The impact of obesity on female reproductive function. Obes. Rev, 2007, No8(6), рр.515-23.</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Michalakis K., Mintziori G., Kaprara A. The complex interaction between obesity, metabolic syndrome and reproductive axis: a narrative review. Metabolism,2013, No62(4), рр.457-78.</mixed-citation><mixed-citation xml:lang="en">Michalakis K., Mintziori G., Kaprara A. The complex interaction between obesity, metabolic syndrome and reproductive axis: a narrative review. Metabolism,2013, No62(4), рр.457-78.</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Moran L.J., Norman R.J. The obese patient with infertility: a practical approach to diagnosis and treatment. Nutr Clin Care,2002, V.5(6), рр.290-297.</mixed-citation><mixed-citation xml:lang="en">Moran L.J., Norman R.J. The obese patient with infertility: a practical approach to diagnosis and treatment. Nutr Clin Care,2002, V.5(6), рр.290-297.</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">Motta A.B. The role of obesity in the development of polycystic ovary syndrome. Curr. Pharm. Des, 2012, No18(17), рр.2482-91.</mixed-citation><mixed-citation xml:lang="en">Motta A.B. The role of obesity in the development of polycystic ovary syndrome. Curr. Pharm. Des, 2012, No18(17), рр.2482-91.</mixed-citation></citation-alternatives></ref><ref id="cit56"><label>56</label><citation-alternatives><mixed-citation xml:lang="ru">Nelson S.M., Fleming R. Obesity and reproduction: impact and interventions. Curr Opin Obstet Gynecol,2007, V.19(4), рр.384-389.</mixed-citation><mixed-citation xml:lang="en">Nelson S.M., Fleming R. Obesity and reproduction: impact and interventions. Curr Opin Obstet Gynecol,2007, V.19(4), рр.384-389.</mixed-citation></citation-alternatives></ref><ref id="cit57"><label>57</label><citation-alternatives><mixed-citation xml:lang="ru">Nelson S.M., Flemming R.F. The preconceptual contraception paradigm: obesity and infertility. Hum Reprod, 2007, V.22(4), рр.912-915.</mixed-citation><mixed-citation xml:lang="en">Nelson S.M., Flemming R.F. The preconceptual contraception paradigm: obesity and infertility. Hum Reprod, 2007, V.22(4), рр.912-915.</mixed-citation></citation-alternatives></ref><ref id="cit58"><label>58</label><citation-alternatives><mixed-citation xml:lang="ru">Ogbuji Q.C. Obesity and reproductive performance in women. Afr. J. Reprod. Health,2010, No14(3), рр.143–51.</mixed-citation><mixed-citation xml:lang="en">Ogbuji Q.C. Obesity and reproductive performance in women. Afr. J. Reprod. Health,2010, No14(3), рр.143–51.</mixed-citation></citation-alternatives></ref><ref id="cit59"><label>59</label><citation-alternatives><mixed-citation xml:lang="ru">Rosenfield R.L., Barnes R.B., Cara J.F. Dysregulation of cytochrome P450c 17 alpha as the cause of PCOS. Fertil Steril, 1990, V.53, рр.785-791.</mixed-citation><mixed-citation xml:lang="en">Rosenfield R.L., Barnes R.B., Cara J.F. Dysregulation of cytochrome P450c 17 alpha as the cause of PCOS. Fertil Steril, 1990, V.53, рр.785-791.</mixed-citation></citation-alternatives></ref><ref id="cit60"><label>60</label><citation-alternatives><mixed-citation xml:lang="ru">Safer DJ. Diet, behavior modification, and exercise: A review of obesity treatments from a long–term perspective. South Med J.,1991, V.84.</mixed-citation><mixed-citation xml:lang="en">Safer DJ. Diet, behavior modification, and exercise: A review of obesity treatments from a long–term perspective. South Med J.,1991, V.84.</mixed-citation></citation-alternatives></ref><ref id="cit61"><label>61</label><citation-alternatives><mixed-citation xml:lang="ru">Salley K.E., Wickham E.P., Cheang K.I. Position Statement: Glucose intolerance in polycystic ovary syndrome a position statement of the Androgen Excess Society. JCE&amp;M. 2007, V.92, рр.4546-4556.</mixed-citation><mixed-citation xml:lang="en">Salley K.E., Wickham E.P., Cheang K.I. Position Statement: Glucose intolerance in polycystic ovary syndrome a position statement of the Androgen Excess Society. JCE&amp;M. 2007, V.92, рр.4546-4556.</mixed-citation></citation-alternatives></ref><ref id="cit62"><label>62</label><citation-alternatives><mixed-citation xml:lang="ru">Shekelle PG, Newberry S, Maglione M, Li Z, Yermilov I et. al. Bariatric surgery in women of reproductive age: special concerns for pregnancy. Evid Rep Technol Assess,2008, V.169, рр.1-51.</mixed-citation><mixed-citation xml:lang="en">Shekelle PG, Newberry S, Maglione M, Li Z, Yermilov I et. al. Bariatric surgery in women of reproductive age: special concerns for pregnancy. Evid Rep Technol Assess,2008, V.169, рр.1-51.</mixed-citation></citation-alternatives></ref><ref id="cit63"><label>63</label><citation-alternatives><mixed-citation xml:lang="ru">Skov V., Glintborg D., Knudsen S. Reduced expression of nuclearencoded genes involved in mitochondrial oxidative metabolism in skeletal muscle of insulin-resistant women with PCOS. Diabetes, 2007, V.56,рр.2349-2355.</mixed-citation><mixed-citation xml:lang="en">Skov V., Glintborg D., Knudsen S. Reduced expression of nuclearencoded genes involved in mitochondrial oxidative metabolism in skeletal muscle of insulin-resistant women with PCOS. Diabetes, 2007, V.56,рр.2349-2355.</mixed-citation></citation-alternatives></ref><ref id="cit64"><label>64</label><citation-alternatives><mixed-citation xml:lang="ru">Skubleny D, Switzer NJ, Gill RS, et al. The impact of bariatric surgery on polycystic ovary syndrome: a systematic review and meta-analysis. Obes Surg, 2016, V.26(1), рр.169-76.</mixed-citation><mixed-citation xml:lang="en">Skubleny D, Switzer NJ, Gill RS, et al. The impact of bariatric surgery on polycystic ovary syndrome: a systematic review and meta-analysis. Obes Surg, 2016, V.26(1), рр.169-76.</mixed-citation></citation-alternatives></ref><ref id="cit65"><label>65</label><citation-alternatives><mixed-citation xml:lang="ru">Stofkova A. Resistin and visfatin: regulators of insulin sensitivity, inflammation and immunity. Endocr. Regul,2010, No44(1), рр.25–36.</mixed-citation><mixed-citation xml:lang="en">Stofkova A. Resistin and visfatin: regulators of insulin sensitivity, inflammation and immunity. Endocr. Regul,2010, No44(1), рр.25–36.</mixed-citation></citation-alternatives></ref><ref id="cit66"><label>66</label><citation-alternatives><mixed-citation xml:lang="ru">Sturm R. Increases in clinically severe obesity in the United States, 1986– 2000. Arch Intern Med, 2003, No163(18), рр.2146-2148.</mixed-citation><mixed-citation xml:lang="en">Sturm R. Increases in clinically severe obesity in the United States, 1986– 2000. Arch Intern Med, 2003, No163(18), рр.2146-2148.</mixed-citation></citation-alternatives></ref><ref id="cit67"><label>67</label><citation-alternatives><mixed-citation xml:lang="ru">Velazquez E.M., Mendoza S., Hamer T. Metformin therapy in PCOS reduces hyperinsulinemia, insulin resistance, hyperandrogenemia, and systolic blood pressure, while facilitating normal menses and pregnancy. Metabol, 1994, V.43, рр.647-654.</mixed-citation><mixed-citation xml:lang="en">Velazquez E.M., Mendoza S., Hamer T. Metformin therapy in PCOS reduces hyperinsulinemia, insulin resistance, hyperandrogenemia, and systolic blood pressure, while facilitating normal menses and pregnancy. Metabol, 1994, V.43, рр.647-654.</mixed-citation></citation-alternatives></ref><ref id="cit68"><label>68</label><citation-alternatives><mixed-citation xml:lang="ru">Volkan Yumuk et. al. European Guidelines for Obesity Management in Adults. Obes Facts,2015, V.8,рр.402–424 .</mixed-citation><mixed-citation xml:lang="en">Volkan Yumuk et. al. European Guidelines for Obesity Management in Adults. Obes Facts,2015, V.8,рр.402–424</mixed-citation></citation-alternatives></ref><ref id="cit69"><label>69</label><citation-alternatives><mixed-citation xml:lang="ru">Wang Y., Beydoun M. A., Liang L. et al. Will all americans become overweight or obese. Estimating the progression and cost of the US obesity epidemic. Obesity, 2008, No16(10), рр.2323-2330.</mixed-citation><mixed-citation xml:lang="en">Wang Y., Beydoun M. A., Liang L. et al. Will all americans become overweight or obese. Estimating the progression and cost of the US obesity epidemic. Obesity, 2008, No16(10), рр.2323-2330.</mixed-citation></citation-alternatives></ref><ref id="cit70"><label>70</label><citation-alternatives><mixed-citation xml:lang="ru">Weng T.-C., Chang C.-H., Dong Y.-H., Chang Y.-C., Chuang L.-M. Anaemia and related nutrient deficiencies after Rouxen-Y gastric bypass surgery: a systematic review and meta-analysis. BMJ Open, 2015, V.5(7).</mixed-citation><mixed-citation xml:lang="en">Weng T.-C., Chang C.-H., Dong Y.-H., Chang Y.-C., Chuang L.-M. Anaemia and related nutrient deficiencies after Roux-en-Y gastric bypass surgery: a systematic review and meta-analysis. BMJ Open, 2015, V.5(7).</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
